Starch nanoparticles (SNP) were modified with synthetic polymers using the “grafting to” approach and nitroxide-mediated polymerization. SG1-capped poly(methyl methacrylate-co-styrene) (P(MMA-co-S)) copolymers with low dispersity and high degree of livingness were first synthesized in bulk. These macroalkoxyamines were then grafted to vinyl benzyl-functionalized SNP to obtain biosynthetic hybrids. The grafted materials, SNP-g-P(MMA-co-S), were characterized by ¹H NMR, FTIR, TGA, and elemental analysis. The total amount of grafted polymer and the grafting efficiency were evaluated for different molecular weights (5870–12150 g·mol^–1) of the grafted polymer, the polymer addition approach (batch or semibatch) and the initial polymer loading (2.5, 5, or 10 g polymer/g SNP). The proposed approach presented in this work to graft modify SNP allows for a precise surface modification of the nanoparticles, while permitting that the final properties of the resulting biohybrid to be tunable according to the choice of polymer grafted.

中文翻译：

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使用一氧化氮介导的聚合反应和“接枝到”方法对淀粉纳米粒子进行接枝改性。

淀粉纳米颗粒（SNP）使用“接枝到”方法和一氧化氮介导的聚合反应用合成聚合物改性。首先散装合成了具有低分散性和高活度的SG1封端的聚（甲基丙烯酸甲酯-共苯乙烯）（P（MMA-共-S））共聚物。然后将这些大烷氧基胺接枝到乙烯基苄基官能化的SNP上，以获得生物合成的杂种。通过¹ H NMR，FTIR，TGA和元素分析对接枝材料SNP- g -P（MMA- co -S）进行了表征。对不同分子量（5870–12150 g·mol ^–1）的接枝聚合物总量和接枝效率进行了评估。），接枝聚合物的方法（间歇或半间歇）和初始聚合物负载量（2.5、5或10 g聚合物/ g SNP）。这项工作中提出的接枝修饰SNP的方法允许对纳米粒子进行精确的表面修饰，同时允许根据所接枝聚合物的选择调整最终生物杂交体的最终性能。