Silver nanoparticles (AgNPs) are utilized in surgical implants and medical textiles, thus providing access to the circulation. While research has been conducted primarily in healthy models, AgNP-induced toxicity evaluations in disease conditions are critical, as many individuals have preexisting conditions. Specifically, over 20% of United States adults suffer from metabolic syndrome (MetS). It was hypothesized that MetS may increase susceptibility to AgNP-mediated toxicity due to induction of differential inflammation and altered biodistribution. Mice were injected with 2 mg/kg AgNPs, and organs assessed for inflammatory gene expression (TNF-α, CXCL1, CXCL2, CCL2, TGF-β, HO-1, IL-4, IL-13), and Ag content. AgNPs were determined to induce differential inflammation in healthy and MetS mice. While AgNP exposure increased TNF-α, CXCL1, TGF-β, HO-1, and IL-4 expression within healthy mouse spleens, MetS-treated animals demonstrated decreased CXCL1, IL-4, and IL-13 expression. Healthy and MetS mice livers exhibited similar inflammatory responses to one another. AgNPs localized primarily to the liver and spleen, although Ag was present in all examined organs. In organs of minor AgNP deposition, such as kidney, gene expression was variable. Induction of inflammatory genes did not correspond with biodistribution, suggesting disease-related variations in AgNP-mediated adverse responses. These findings indicate that disease may influence inflammation and biodistribution, impacting AgNP clinical applications.

中文翻译：

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健康和代谢综合征小鼠模型之间银纳米颗粒诱导的炎症反应的比较。

银纳米颗粒（AgNPs）用于外科植入物和医用纺织品中，从而提供了进入流通的通道。尽管研究主要是在健康模型中进行的，但由于许多人都已患病，因此AgNP诱导的疾病状况毒性评估至关重要。具体而言，超过20％的美国成年人患有代谢综合症（MetS）。据推测，由于诱导差异性炎症和改变的生物分布，MetS可能增加对AgNP介导的毒性的敏感性。给小鼠注射2mg / kg的AgNP，并评估器官的炎性基因表达（TNF-α，CXCL1，CXCL2，CCL2，TGF-β，HO-1，IL-4，IL-13）和Ag含量。确定了AgNP在健康和MetS小鼠中诱导差异性炎症。AgNP暴露会增加TNF-α，CXCL1，TGF-β，HO-1，和健康小鼠脾脏中的IL-4表达，经MetS处理的动物表现出CXCL1，IL-4和IL-13表达降低。健康小鼠和MetS小鼠的肝脏相互之间表现出相似的炎症反应。尽管Ag存在于所有检查的器官中，但AgNPs主要定位于肝脏和脾脏。在较小的AgNP沉积器官（例如肾脏）中，基因表达是可变的。炎症基因的诱导与生物分布不符，表明AgNP介导的不良反应中与疾病有关的变异。这些发现表明，疾病可能会影响炎症和生物分布，从而影响AgNP的临床应用。健康小鼠和MetS小鼠的肝脏相互之间表现出相似的炎症反应。尽管Ag存在于所有检查的器官中，但AgNPs主要定位于肝脏和脾脏。在较小的AgNP沉积器官（例如肾脏）中，基因表达是可变的。炎症基因的诱导与生物分布不符，表明AgNP介导的不良反应中与疾病有关的变异。这些发现表明，疾病可能会影响炎症和生物分布，从而影响AgNP的临床应用。健康小鼠和MetS小鼠的肝脏相互之间表现出相似的炎症反应。尽管Ag存在于所有检查的器官中，但AgNPs主要定位于肝脏和脾脏。在较小的AgNP沉积器官（例如肾脏）中，基因表达是可变的。炎症基因的诱导与生物分布不符，表明AgNP介导的不良反应中与疾病有关的变异。这些发现表明，疾病可能会影响炎症和生物分布，从而影响AgNP的临床应用。表明AgNP介导的不良反应与疾病有关。这些发现表明，疾病可能会影响炎症和生物分布，从而影响AgNP的临床应用。表明AgNP介导的不良反应与疾病有关。这些发现表明，疾病可能会影响炎症和生物分布，从而影响AgNP的临床应用。