Sickle cell disease is associated with numerous symptoms and complications. Acute painful crisis is the most characteristic manifestation of the disease. In addition, many patients report chronic pain. As both acute and chronic pain severely diminish quality of life, adequate pain management is crucial. Recommendations for the treatment of acute painful crises are based on the World Health Organization analgesic ladder, which has been developed for cancer-related pain. Chronic pain can be treated with basic long-acting opioids and on-demand short-acting opioids. If patients show signs of neuropathic pain, administration of anticonvulsants, antidepressants or possibly ketamine should be considered.

中文翻译：

---

Schmerztherapie bei Sichelzellkrankheit

镰状细胞病与许多症状和并发症有关。急性疼痛危象是该病最典型的表现。此外，许多患者报告慢性疼痛。由于急性和慢性疼痛都会严重降低生活质量，因此适当的疼痛管理至关重要。治疗急性疼痛危象的建议基于世界卫生组织镇痛阶梯，该阶梯是针对癌症相关疼痛制定的。慢性疼痛可以用基本的长效阿片类药物和按需短效阿片类药物治疗。如果患者出现神经性疼痛的迹象，应考虑使用抗惊厥药、抗抑郁药或氯胺酮。