Ionic channel blockage and multiple oscillatory signals play an important role in the dynamical response of pulse sequences. The effects of ionic channel blockage and ionic channel noise on the discharge behaviors are studied in Hodgkin–Huxley neuronal model with multiple oscillatory signals. It is found that bifurcation points of spontaneous discharge are altered through tuning the amplitude of multiple oscillatory signals, and the discharge cycle is changed by increasing the frequency of multiple oscillatory signals. The effects of ionic channel blockage on neural discharge behaviors indicate that the neural excitability can be suppressed by the sodium channel blockage, however, the neural excitability can be reversed by the potassium channel blockage. There is an optimal blockage ratio of potassium channel at which the electrical activity is the most regular, while the order of neural spike is disrupted by the sodium channel blockage. In addition, the frequency of spike discharge is accelerated by increasing the ionic channel noise, the firing of neuron becomes more stable if the ionic channel noise is appropriately reduced. Our results might provide new insights into the effects of ionic channel blockages, multiple oscillatory signals, and ionic channel noises on neural discharge behaviors.

中文翻译：

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由多个振荡信号驱动的随机 Hodgkin-Huxley 神经元模型中的离子通道阻塞。

离子通道阻塞和多个振荡信号在脉冲序列的动态响应中起着重要作用。在具有多个振荡信号的 Hodgkin-Huxley 神经元模型中研究了离子通道阻塞和离子通道噪声对放电行为的影响。发现通过调节多个振荡信号的幅度来改变自发放电的分叉点，通过增加多个振荡信号的频率来改变放电周期。离子通道阻滞对神经放电行为的影响表明，钠通道阻滞可抑制神经兴奋性，而钾通道阻滞可逆转神经兴奋性。钾通道有一个最佳阻滞比例，此时电活动最为规律，而钠通道阻滞扰乱了神经尖峰的顺序。此外，增加离子通道噪声会加快尖峰放电的频率，如果离子通道噪声适当降低，神经元的放电会更加稳定。我们的结果可能为离子通道阻塞、多个振荡信号和离子通道噪声对神经放电行为的影响提供新的见解。