A thermoplastic microfluidic substrate is conformally integrated onto the cylindrical barrel of a conventional venipuncture syringe, forming a spiral inertial separation element supporting the isolation of plasma from diluted whole blood. The cylindrical shape of the syringe itself serves to define the flow path required for inertial separation by transforming a linear microchannel to a spiral topology. The hybrid system enables inertial plasma separation by Dean flow focusing within the same syringe used for a patient blood draw, with the seamlessly interconnected microfluidic element operated by automated or manual actuation of the syringe plunger. Plasma isolation is achieved without the need for external instrumentation. Device design and fabrication challenges are discussed, and effective plasma isolation within the system is demonstrated, with a peak separation efficiency above 97% using 25 × diluted blood.

中文翻译：

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通过惯性微流体的共形集成在注射器中隔离等离子体。

热塑性微流体基板共形地集成到传统静脉穿刺注射器的圆柱筒上，形成螺旋惯性分离元件，支持从稀释的全血中分离血浆。注射器本身的圆柱形形状用于通过将线性微通道转换为螺旋拓扑来定义惯性分离所需的流动路径。混合系统通过在用于患者抽血的同一注射器内聚焦 Dean 流来实现惯性血浆分离，无缝互连的微流体元件通过注射器柱塞的自动或手动致动进行操作。无需外部仪器即可实现等离子体隔离。讨论了设备设计和制造挑战，并展示了系统内的有效等离子体隔离，