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Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective.
Chemico-Biological Interactions ( IF 4.7 ) Pub Date : 2020-05-04 , DOI: 10.1016/j.cbi.2020.109125
Parteek Prasher 1 , Mousmee Sharma 2 , Meenu Mehta 3 , Keshav R Paudel 4 , Saurabh Satija 5 , Dinesh K Chellappan 6 , Harish Dureja 7 , Gaurav Gupta 8 , Murtaza M Tambuwala 9 , Poonam Negi 10 , Peter R Wich 11 , Nicole G Hansbro 12 , Philip M Hansbro 13 , Kamal Dua 14
Affiliation  

The apparent predicament of the representative chemotherapy for managing respiratory distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively counter the contemporary intricacies associated with target disease. Multiple, complex regulatory pathways manifest chronic pulmonary disorders, which require chemotherapeutics that produce composite inhibitory effect. The cost effective natural product based molecules hold a high fervor to meet the prospects posed by current respiratory-distress therapy by sparing the tedious drug design and development archetypes, present a robust standing for the possible replacement of the fading practice of poly-pharmacology, and ensure the subversion of a potential disease relapse. This study summarizes the experimental evidences on natural products moieties and their components that illustrates therapeutic efficacy on respiratory disorders.

中文翻译:

植物衍生针对慢性呼吸道疾病的治疗策略:化学和免疫学观点。

用于管理呼吸窘迫的代表性化疗的明显困境要求对确定有效对抗与目标疾病相关的当代错综复杂的药物进行强制性审议。多种复杂的调节途径表现为慢性肺部疾病,这需要产生复合抑制作用的化学疗法。具有成本效益的基于天然产物的分子通过避免繁琐的药物设计和开发原型来满足当前呼吸窘迫疗法所带来的前景,为可能替代多药理学的衰落实践提供了强有力的支持,并且确保颠覆潜在的疾病复发。
更新日期:2020-05-04
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