Adverse effects of pesticides on the functions of immune system.,Comparative Biochemistry and Physiology C: Toxicology & Pharmacology

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Adverse effects of pesticides on the functions of immune system.
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2020-05-03 , DOI: 10.1016/j.cbpc.2020.108789
Gun-Hwi Lee ₁ , Kyung-Chul Choi ₁

Affiliation

Pesticides are chemical substances used to kill unwanted fungi, weeds and insects. In many countries, there is currently concern regarding the adverse effects of pesticides on health. It has been reported that pesticides may cause cancer, respiratory diseases, organ diseases, system failures, nervous system disorders and asthma, which are closely connected with immune disorders. Therefore, this study reviewed the immunotoxicity of pesticides that are currently used or prohibited from being used, especially their effects on leukocytes such as T cells, B cells, NK cells and macrophages. These immune cells play crucial roles in innate and adaptive immune systems to protect hosts. Pesticides are known to have possible toxicological modes of action to induce oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress in living organisms. According to previous studies, pesticides such as atrazine (ATR), organophophorus (OP) compounds, carbamates, and pyrethroids were shown to inhibit the survival and growth of leukocytes by inducing apoptosis or cell cycle arrest and interfering with the specific immunological functions of each type of immune cells. These results suggest the immunotoxicity of pesticides toward specific immune cells. To substantiate the overall immunocompromised effects of pesticides, there is a need to collect and thoroughly analyze additional information regarding other immunological toxicities.

中文翻译：

农药对免疫系统功能的不利影响。

农药是用于杀死有害真菌，杂草和昆虫的化学物质。在许多国家，目前对农药对健康的不利影响感到关注。据报道，农药可能引起癌症，呼吸系统疾病，器官疾病，系统衰竭，神经系统疾病和哮喘，这与免疫疾病密切相关。因此，本研究回顾了目前使用或禁止使用的农药的免疫毒性，特别是其对白细胞（如T细胞，B细胞，NK细胞和巨噬细胞）的影响。这些免疫细胞在先天性和适应性免疫系统中起着至关重要的作用，以保护宿主。已知农药具有可能引起氧化应激，线粒体功能障碍，和生物体内的内质网（ER）应激。根据以前的研究，农药阿特拉津（ATR），有机磷（OP）化合物，氨基甲酸酯和拟除虫菊酯显示通过诱导凋亡或细胞周期停滞并干扰每种类型的特定免疫功能来抑制白细胞的存活和生长。免疫细胞。这些结果表明了农药对特定免疫细胞的免疫毒性。为了证实农药的整体免疫功能受损，需要收集并彻底分析有关其他免疫毒性的其他信息。拟除虫菊酯和拟除虫菊酯通过诱导细胞凋亡或细胞周期停滞并干扰每种类型免疫细胞的特定免疫功能来抑制白细胞的存活和生长。这些结果表明了农药对特定免疫细胞的免疫毒性。为了证实农药的整体免疫功能受损，需要收集并彻底分析有关其他免疫毒性的其他信息。拟除虫菊酯和拟除虫菊酯通过诱导凋亡或细胞周期停滞并干扰每种类型免疫细胞的特定免疫功能来抑制白细胞的存活和生长。这些结果表明了农药对特定免疫细胞的免疫毒性。为了证实农药的整体免疫功能受损，需要收集并彻底分析有关其他免疫毒性的其他信息。

更新日期：2020-05-03

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