Post-translational modifications (PTMs) such as phosphorylation, ubiquitination or glycosylation are processes affecting the conformation, stability, localization and function of proteins. There is clear evidence that PTMs can act upon tight junction (TJ) proteins, thus modulating epithelial barrier function. Compared to transcriptional or translational regulation, PTMs are rapid and more dynamic processes so in the context of barrier maintenance they might be essential for coping with changing environmental or external impacts. The aim of this review is to extract literature deciphering PTMs in TJ proteins directly contributing to epithelial barrier changes in permeability to ions and macromolecules. It is not intended to cover the entire scope of PTMs in TJ proteins and should rather be understood as a digest of TJ protein modifications directly resulting in the tightening or opening of the epithelial barrier.

中文翻译：

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紧密连接跨膜蛋白的翻译后修饰及其对屏障功能的直接影响。

翻译后修饰（PTM），例如磷酸化，泛素化或糖基化是影响蛋白质构象，稳定性，定位和功能的过程。有明确的证据表明PTM可以作用于紧密连接（TJ）蛋白，从而调节上皮屏障功能。与转录或翻译调控相比，PTM是快速且动态的过程，因此在屏障维护的背景下，它们可能对于应对不断变化的环境或外部影响至关重要。这篇综述的目的是从TJ蛋白中提取破译PTM的文献，这些文献直接导致上皮屏障对离子和大分子通透性的改变。