Background

Hepatectomy and liver transplantation (LT) are the two most commonly performed surgical procedures for various hepatic lesions. microRNA (miRNA) and long non-coding RNA (lncRNA) have been gradually unveiled their roles as either biomarkers for early diagnosis or potentially therapeutic tools to manipulate gene expression in many disease entities. This review aimed to discuss the effects of miRNA or lncRNA in the hepatectomy and LT fields.

Data sources

We did a literature search from 1990 through January 2018 to summarize the currently available evidence with respect to the effects of miRNA and lncRNA in liver regeneration after partial hepatectomy, as well as their involvement in several key issues related to LT, including ischemia-reperfusion injury, allograft rejection, tolerance, recurrence of original hepatic malignancies, etc.

Results

Certain miRNAs and lncRNAs are actively involved in the regulation of various aspects of liver resection and transplantation. During the process of liver regeneration after hepatectomy, the expression of miRNAs and lncRNAs shows dynamic changes.

Conclusions

It is now clear that miRNAs and lncRNAs orchestrate in various aspects of the pathophysiological process of LT and hepatectomy. Better understanding of the underlying mechanism and future clinical trials may strengthen their positions as either biomarkers or potential therapeutic targets in the management of complications after liver surgery.

中文翻译：

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肝脏手术中的MicroRNA和长非编码RNA：诊断和治疗价值。

背景

肝切除术和肝移植（LT）是针对各种肝病变最常用的两种手术方法。microRNA（miRNA）和长非编码RNA（lncRNA）逐渐被揭示，它们可以作为早期诊断的生物标志物或操纵许多疾病实体中基因表达的潜在治疗工具。这篇综述旨在讨论miRNA或lncRNA在肝切除术和LT领域的作用。

数据源

我们从1990年到2018年1月进行了文献检索，以总结关于miRNA和lncRNA在部分肝切除术后肝脏再生中的作用以及它们参与与LT相关的几个关键问题（包括缺血再灌注损伤）的现有证据，同种异体移植排斥，耐受性，原发性肝恶性肿瘤复发等。

结果

某些miRNA和lncRNA积极参与肝脏切除和移植各个方面的调节。肝切除术后肝再生过程中，miRNA和lncRNA的表达呈动态变化。

结论

现在很清楚，miRNA和lncRNA在LT和肝切除术的病理生理过程的各个方面进行编排。更好地了解其潜在机制和未来的临床试验可能会加强其在肝脏手术后并发症管理中作为生物标志物或潜在治疗靶标的地位。