Gas-Sensing Transcriptional Regulators.,Biotechnology Journal

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Gas-Sensing Transcriptional Regulators.
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-05-03 , DOI: 10.1002/biot.201900345
Irisappan Ganesh ₁ , Da-Ae Gwon ₁ , Jeong Wook Lee _{1,

2}

Affiliation

Gas molecules are ubiquitous in the environment and are used as nutrient and energy sources for living organisms. Many organisms, therefore, have developed gas‐sensing systems to respond efficiently to changes in the atmospheric environment. In microorganisms and plants, two‐component systems (TCSs) and transcription factors (TFs) are two primary mechanisms to sense gas molecules. In this review, gas‐sensing transcriptional regulators, TCSs, and TFs, focusing on protein structures, mechanisms of gas molecule interaction, DNA binding regions of transcriptional regulators, signal transduction mechanisms, and gene expression regulation are discussed. At first, transcriptional regulators that directly sense gas molecules with the help of a prosthetic group is described and then gas‐sensing systems that indirectly recognize the presence of gas molecules is explained. Overall, this review provides a comprehensive understanding of gas‐sensing transcriptional regulators in microorganisms and plants, and proposes a future perspective on the use of gas‐sensing transcriptional regulators.

中文翻译：

气体传感转录调节剂。

气体分子在环境中无处不在，并被用作生物体的营养和能源。因此，许多生物已经开发出了气体传感系统，可以有效地响应大气环境的变化。在微生物和植物中，双组分系统（TCS）和转录因子（TFs）是检测气体分子的两个主要机制。在这篇综述中，讨论了气敏转录调节剂，TCS和TF，重点是蛋白质结构，气体分子相互作用的机制，转录调节剂的DNA结合区域，信号转导机制和基因表达调节。首先，描述了借助修复基团直接感测气体分子的转录调节剂，然后介绍了间接识别气体分子存在的气体传感系统。总体而言，本综述全面了解了微生物和植物中的气敏转录调节因子，并提出了使用气敏转录调节因子的未来观点。

更新日期：2020-05-03

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