当前位置：
X-MOL 学术
›
Int. J. Numer. Method. Biomed. Eng.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves.
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-05-08 , DOI: 10.1002/cnm.3346 Devin W Laurence 1 , Emily L Johnson 2 , Ming-Chen Hsu 2 , Ryan Baumwart 3 , Arshid Mir 4 , Harold M Burkhart 5 , Gerhard A Holzapfel 6, 7 , Yi Wu 1 , Chung-Hao Lee 1, 8
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-05-08 , DOI: 10.1002/cnm.3346 Devin W Laurence 1 , Emily L Johnson 2 , Ming-Chen Hsu 2 , Ryan Baumwart 3 , Arshid Mir 4 , Harold M Burkhart 5 , Gerhard A Holzapfel 6, 7 , Yi Wu 1 , Chung-Hao Lee 1, 8
Affiliation
|
Current clinical assessment of functional tricuspid valve regurgitation relies on metrics quantified from medical imaging modalities. Although these clinical methodologies are generally successful, the lack of detailed information about the mechanical environment of the valve presents inherent challenges for assessing tricuspid valve regurgitation. In the present study, we have developed a finite element‐based in silico model of one porcine tricuspid valve (TV) geometry to investigate how various pathological conditions affect the overall biomechanical function of the TV. There were three primary observations from our results. Firstly, the results of the papillary muscle (PM) displacement study scenario indicated more pronounced changes in the TV biomechanical function. Secondly, compared to uniform annulus dilation, nonuniform dilation scenario induced more evident changes in the von Mises stresses (83.8‐125.3 kPa vs 65.1‐84.0 kPa) and the Green‐Lagrange strains (0.52‐0.58 vs 0.47‐0.53) for the three TV leaflets. Finally, results from the pulmonary hypertension study scenario showed opposite trends compared to the PM displacement and annulus dilation scenarios. Furthermore, various chordae rupture scenarios were simulated, and the results showed that the chordae tendineae attached to the TV anterior and septal leaflets may be more critical to proper TV function. This in silico modeling‐based study has provided a deeper insight into the tricuspid valve pathologies that may be useful, with moderate extensions, for guiding clinical decisions.
中文翻译：
三尖瓣生物力学功能病理学影响的基于计算机建模的试点研究。
目前对功能性三尖瓣反流的临床评估依赖于从医学成像模式量化的指标。虽然这些临床方法通常是成功的，但缺乏有关瓣膜机械环境的详细信息对评估三尖瓣返流提出了固有的挑战。在本研究中，我们开发了一种基于有限元的计算机模拟一只猪三尖瓣 (TV) 几何模型，以研究各种病理条件如何影响 TV 的整体生物力学功能。我们的结果有三个主要观察结果。首先，乳头肌 (PM) 位移研究情景的结果表明 TV 生物力学功能发生了更明显的变化。其次，与均匀环状扩张相比，非均匀扩张情况导致三个 TV 的 von Mises 应力（83.8-125.3 kPa vs 65.1-84.0 kPa）和 Green-Lagrange 应变（0.52-0.58 vs 0.47-0.53）发生更明显的变化传单。最后，与 PM 位移和瓣环扩张情景相比，肺动脉高压研究情景的结果显示出相反的趋势。此外，还模拟了各种腱索断裂场景，结果表明，附在三尖瓣前叶和隔叶上的腱索对三尖瓣的正常功能可能更为关键。这基于计算机模拟的研究提供了对三尖瓣病变的更深入了解，适度扩展可能有助于指导临床决策。
更新日期：2020-05-08
中文翻译：
三尖瓣生物力学功能病理学影响的基于计算机建模的试点研究。
目前对功能性三尖瓣反流的临床评估依赖于从医学成像模式量化的指标。虽然这些临床方法通常是成功的，但缺乏有关瓣膜机械环境的详细信息对评估三尖瓣返流提出了固有的挑战。在本研究中，我们开发了一种基于有限元的计算机模拟一只猪三尖瓣 (TV) 几何模型，以研究各种病理条件如何影响 TV 的整体生物力学功能。我们的结果有三个主要观察结果。首先，乳头肌 (PM) 位移研究情景的结果表明 TV 生物力学功能发生了更明显的变化。其次，与均匀环状扩张相比，非均匀扩张情况导致三个 TV 的 von Mises 应力（83.8-125.3 kPa vs 65.1-84.0 kPa）和 Green-Lagrange 应变（0.52-0.58 vs 0.47-0.53）发生更明显的变化传单。最后，与 PM 位移和瓣环扩张情景相比，肺动脉高压研究情景的结果显示出相反的趋势。此外，还模拟了各种腱索断裂场景，结果表明，附在三尖瓣前叶和隔叶上的腱索对三尖瓣的正常功能可能更为关键。这基于计算机模拟的研究提供了对三尖瓣病变的更深入了解，适度扩展可能有助于指导临床决策。
京公网安备 11010802027423号