Periconception interactions between maternal conditions and environmental and genetic factors are involved in the pathogenesis and prevention of neural tube defects (NTD), such as spina bifida. These factors have in common that they can impair the oxidative pathway, resulting in excessive (chronic) oxidative stress and inflammation.

中文翻译：

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孕前端粒长度作为评估后代脊柱裂风险的新型母体生物标志物。

母体状况与环境和遗传因素之间的围孕期相互作用涉及神经管缺陷 (NTD)（如脊柱裂）的发病机制和预防。这些因素的共同点是它们会损害氧化途径，导致过度（慢性）氧化应激和炎症。