Introduction: Tuberculosis (TB) is still one of the major global health threats and delayed diagnosis or misdiagnosis continues to fuel the global epidemic. The conventional diagnostic approaches have shortcomings that might hinder the process of diagnosis of the disease and ultimately affect the prognosis.Area covered: We emphasize on the process of the synthesis of liposomes, its physicochemical properties affecting the formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a light on other nanoparticle-based molecular diagnostic approaches for TB. Despite the advent of science, we are yet to have a diagnostic tool that is simple, rapid, sensitive, and specific, and most importantly, one that enables us to demarcate patients with active tuberculosis from those with quiescent lesions, prior vaccination, or other diseases.Expert opinion: The utility of liposomes for diagnostic purposes has been attempted so as to overcome the challenges posed by conventional diagnostic tools for TB. Through this review, we present insights into liposome formulation and selection processes, various studies that report the use of liposome-based diagnostic tools for TB, as well as the limitations associated with the same that can be improvised to make the technology more efficient.

中文翻译：

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基于脂质体的肺结核和肺外结核诊断的评估。

简介：结核病 (TB) 仍然是主要的全球健康威胁之一，延误诊断或误诊继续助长全球流行病。常规诊断方法存在的缺陷可能会阻碍疾病的诊断过程并最终影响预后。结核病的诊断。该评论还阐明了其他基于纳米颗粒的结核病分子诊断方法。尽管有了科学，我们还没有一种简单、快速、灵敏和特异的诊断工具，最重要的是，它使我们能够将活动性结核病患者与静止病变患者区分开来，先前接种疫苗或其他疾病。专家意见：已尝试将脂质体用于诊断目的，以克服传统结核病诊断工具带来的挑战。通过这篇综述，我们提出了对脂质体配方和选择过程的见解，各种报告使用基于脂质体的结核病诊断工具的研究，以及与此相关的限制，可以即兴发挥以提高技术效率。