Background Penile cancer is a rare malignancy with prevalence higher in areas of high Human Papilloma Virus (HPV) such as Africa, Asia and South America. In middle- and low-income countries where circumcision is not routinely practiced, the rate of penile cancer could be ten times higher. Main body of the abstract A literature review was conducted from 1992 to 2019 using PubMed, Google Scholar, African Journal Online and Google with inclusion of 27 publications with emphasis on the Sub-Saharan literature. Findings revealed that most men with penile cancer in Sub-Saharan Africa (SSA) present with locally advanced to advanced disease with devastating consequences. The option of penile sparing procedure is reduced with most treatment option directed to mutilating surgeries. The lack of appropriate chemotherapy and radiotherapy worsens the prognosis in the region. Short conclusion Human Papilloma Virus (HPV) vaccination may not be cost-effective for most regions in SSA. Therefore, early childhood circumcision might be the best advocated alternative for prevention.

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阴茎癌治疗指南——撒哈拉以南非洲地区的当代回顾

背景 阴茎癌是一种罕见的恶性肿瘤，在非洲、亚洲和南美洲等人乳头瘤病毒 (HPV) 高发地区患病率较高。在不常规进行包皮环切术的中低收入国家，阴茎癌的发病率可能高出十倍。摘要主体使用 PubMed、Google Scholar、African Journal Online 和 Google 进行了 1992 年至 2019 年的文献综述，其中纳入了 27 篇出版物，重点关注撒哈拉以南地区的文献。调查结果显示，撒哈拉以南非洲 (SSA) 地区大多数患有阴茎癌的男性都患有局部晚期至晚期疾病，并带来毁灭性后果。阴茎保留手术的选择减少了，大多数治疗选择都是针对残肢手术。缺乏适当的化疗和放疗会使该地区的预后恶化。简短结论 对于 SSA 的大多数地区来说，人乳头瘤病毒 (HPV) 疫苗接种可能不具有成本效益。因此，儿童早期包皮环切术可能是最受提倡的预防替代方案。