More than 55 million mink skins were produced globally in 2017. As a consequence, a large number of people are employed in mink production worldwide. In Denmark, farmed mink were found to constitute a reservoir of methicillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC) 398 and 6000 mink farm workers in Denmark are potentially exposed to LA-MRSA CC398. The study aim was to elucidate the source of LA-MRSA CC398 in mink farms and to investigate possible transmission to humans. In total, 161 LA-MRSA CC398 isolates from mink (n = 65), mink feed (n = 16) and humans (n = 80) with reported contact to mink, were whole-genome sequenced and compared to 183 LA-MRSA CC398 isolates from Danish pigs and an international collection of 89 S. aureus CC398 isolates. Most of the mink-associated isolates clustered within the predominant LA-MRSA CC398 lineages circulating in the Danish pig production, supporting that pigs are a source of LA-MRSA CC398 in mink feed, mink, and mink farmers.

2017年，全球生产了超过5500万只貂皮。结果，全球有大量人从事貂皮生产。在丹麦，发现养殖的貂皮构成耐甲氧西林的金黄色葡萄球菌（MRSA）克隆复合体（CC）398的库，丹麦的6000名貂皮养殖场工人可能暴露于LA-MRSA CC398。该研究的目的是阐明水貂养殖场中LA-MRSA CC398的来源，并调查可能对人类的传播。共有161个LA-MRSA CC398分离物从水貂（n = 65），水貂饲料（n = 16）和人类（n = 80）与水貂有接触，进行了全基因组测序，并与183 LA-MRSA CC398进行了比较丹麦猪和89的国际性的集合分离小号。金黄色CC398分离株。大多数与水貂有关的分离物都聚集在丹麦养猪生产中流行的主要LA-MRSA CC398谱系中，这证明了猪是水貂饲料，水貂和水貂养殖户的LA-MRSA CC398的来源。