Melanin-concentrating hormone (MCH) is a neuropeptide primarily transcribed in the lateral hypothalamus (LH), with vast projections to many areas throughout the central nervous system that play an important role in motivated behaviors and drug use. Anatomical, pharmacological and genetic studies implicate MCH in mediating the intake and reinforcement of commonly abused substances, acting by influencing several systems including the mesolimbic dopaminergic system, glutamatergic as well as GABAergic signaling and being modulated by inflammatory neuroimmune pathways. Further support for the role of MCH in controlling behavior related to drug use will be discussed as it relates to cerebral ventricular volume transmission and intracellular molecules including cocaine- and amphetamine-regulated transcript peptide, dopamine- and cAMP-regulated phosphoprotein 32 kDa. The primary goal of this review is to introduce and summarize current literature surrounding the role of MCH in mediating the intake and reinforcement of commonly abused drugs, such as alcohol, cocaine, amphetamine, nicotine and opiates.

中文翻译：

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黑色素浓缩激素在药物使用障碍中的作用。

黑色素浓缩激素 (MCH) 是一种主要在下丘脑外侧 (LH) 中转录的神经肽，可广泛投射到整个中枢神经系统的许多区域，在动机行为和药物使用中发挥重要作用。解剖学、药理学和遗传学研究表明 MCH 介导了常见滥用物质的摄入和强化，通过影响包括中脑边缘多巴胺能系统、谷氨酸能和 GABA 能信号在内的多个系统起作用，并受炎症神经免疫通路的调节。将进一步支持 MCH 在控制与药物使用相关的行为中的作用，因为它与脑室容积传输和细胞内分子（包括可卡因和苯丙胺调节的转录肽）有关，多巴胺和 cAMP 调节的磷蛋白 32 kDa。本综述的主要目的是介绍和总结当前关于 MCH 在介导常见滥用药物（如酒精、可卡因、苯丙胺、尼古丁和阿片类药物）的摄入和强化方面的作用的文献。