Patients with Alzheimer disease (AD) produce a variety of errors on confrontation naming that indicate multiple loci of impairment along the naming process in this disease. We correlated brain hypometabolism, measured with 18fluoro-deoxy-glucose positron emission tomography, with semantic and formal errors, as well as nonwords deriving from phonological errors produced in a picture-naming test by 63 patients with AD. Findings suggest that neurodegeneration leads to: (1) phonemic errors, by interfering with phonological short-term memory, or with control over retrieval of phonological or prearticulatory representations, within the left supramarginal gyrus; (2) semantic errors, by disrupting general semantic or visual-semantic representations at the level of the left posterior middle and inferior occipitotemporal cortex, respectively; (3) formal errors, by damaging the lexical-phonological output interface in the left mid-anterior segment of middle and superior temporal gyri. This topography of semantic-lexical-phonological steps of naming is in substantial agreement with dual-stream neurocognitive models of word generation.

中文翻译：

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阿尔茨海默病词汇和语音命名错误的代谢成像研究。


阿尔茨海默病 (AD) 患者在对抗命名上会产生多种错误，这表明该疾病的命名过程中存在多个缺陷位点。我们将用 18 氟脱氧葡萄糖正电子发射断层扫描测量的大脑代谢低下与语义和形式错误以及由 63 名 AD 患者进行的图片命名测试中产生的语音错误产生的非单词相关联。研究结果表明，神经退行性疾病会导致：（1）通过干扰左侧边缘上回的语音短期记忆或控制语音或发音前表征的检索而出现语音错误； (2) 语义错误，分别扰乱左后中枕皮质和下枕颞皮质水平的一般语义或视觉语义表征； (3)形式错误，损害颞中回和上回左侧中前段的词汇-语音输出接口。这种命名的语义-词汇-语音步骤的拓扑与单词生成的双流神经认知模型基本一致。