Our research work was designed to investigate the curative and preventive effects of Carthamus oxycantha root extract against diarrhea and microorganisms. For the antibacterial experiment, the agar well diffusion method was used against standard bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, and Salmonella typhi, while for the assessment of antidiarrheal activity, castor oil and the magnesium sulfate-induced diarrhea method was used on albino, laboratory-bred (BALB/c) mice at a dose rate of 200 and 400 mg/kg (body weight, b.w) orally. The methanol extract of C. oxycantha significantly (p < 0.001) decreased the frequency of defecation, and wet stools in a dose depended on the manner of after receiving magnesium sulfate (2 g/kg (b.w)) and castor oil (1.0 mL/mice). Furthermore, the extract of C. oxycantha showed concentration-dependent antimicrobial properties against S. aureus followed by S. typhi, E. coli, and P. aeroginosa bacterial strains, with inhibitions ranging from 10.5-15 mm. These findings show significant results that C. oxycantha is effective as an antidiarrheal and antibacterial agent. However, further works are needed to establish its mode of action.

中文翻译：

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红花根提取物作为止泻和体外抗菌活性的化学治疗潜力。

我们的研究工作旨在调查红豆根提取物对腹泻和微生物的治疗和预防作用。对于抗菌实验，琼脂井扩散法用于对抗标准细菌金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌和伤寒沙门氏菌，而对于腹泻活性的评估，蓖麻油和硫酸镁诱导的腹泻法用于白化病。 ，以200和400 mg / kg（体重，体重）的口服剂量口服实验室饲养的（BALB / c）小鼠。氧化隐孢子虫的甲醇提取物显着（p <0.001）减少了排便的频率，并且大便潮湿的剂量取决于接受硫酸镁（2 g / kg（bw））和蓖麻油（1.0 mL / ml）后的剂量老鼠）。此外，C的提取物。oxycantha对金黄色葡萄球菌表现出浓度依赖性的抗菌特性，其次是伤寒沙门氏菌，大肠杆菌和铜绿假单胞菌细菌菌株，其抑制作用范围为10.5-15 mm。这些发现显示出显着的结果，即长叶隐孢子虫作为抗腹泻和抗菌剂是有效的。但是，还需要进一步的工作来确定其作用方式。