BACKGROUND AND AIMS The expansion of adipose tissue increases leptin secretion associated with a reduction of adiponectin concentration, which negatively affects health of adolescents with obesity. This study aims to investigate the effects of non-intensive interdisciplinary therapy on cardiometabolic parameters including leptin, adiponectin and adiponectin/leptin ratio as a dependent manner on its magnitude of weight loss reduction. METHODS AND RESULTS Thirty-eight adolescents (14-19 y.o) were enrolled in an interdisciplinary therapy for 20 weeks. Body composition, biochemical parameters, leptin and adiponectin were measured at baseline and after therapy. The adolescents were divided into two groups according to the magnitude of total weight loss, less than 5% (<5%-n = 18) or greater than or equal to 5% (≥5%-n = 20). Leptin decreased in whole group after therapy, while adiponectin, and adiponectin/leptin ratio increased. Additionally, body composition was improved. Only the group who lost ≥5% of body weight could reduce the inflammatory state. CONCLUSION The interdisciplinary therapy contributes to improve cardiometabolic parameters that could be involved on inflammation in adolescents with obesity, this improvement occurred mainly when the weight loss is ≥5% of body weight. It could be a target for control the inflammatory process related to obesity in adolescents.

中文翻译：

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接受多组分治疗的肥胖青少年体重减轻幅度对 Adipo/lep 比率的影响

背景和目的 脂肪组织的扩张会增加与脂联素浓度降低相关的瘦素分泌，从而对肥胖青少年的健康产生负面影响。本研究旨在调查非强化跨学科治疗对心脏代谢参数的影响，包括瘦素、脂联素和脂联素/瘦素比率，作为其减重幅度的依赖方式。方法和结果 38 名青少年（14-19 岁）参加了为期 20 周的跨学科治疗。在基线和治疗后测量身体成分、生化参数、瘦素和脂联素。青少年根据总体重减轻的大小分为两组，小于 5% (<5%-n = 18) 或大于或等于 5% (≥5%-n = 20)。治疗后全组瘦素下降，而脂联素、脂联素/瘦素比值升高。此外，身体成分也得到了改善。只有体重减轻≥5%的组才能减轻炎症状态。结论 跨学科治疗有助于改善可能与肥胖青少年炎症有关的心脏代谢参数，这种改善主要发生在体重减轻≥体重的 5% 时。它可能是控制与青少年肥胖相关的炎症过程的目标。结论 跨学科治疗有助于改善可能与肥胖青少年炎症有关的心脏代谢参数，这种改善主要发生在体重减轻≥体重的 5% 时。它可能是控制与青少年肥胖相关的炎症过程的目标。结论 跨学科治疗有助于改善可能与肥胖青少年炎症有关的心脏代谢参数，这种改善主要发生在体重减轻≥体重的 5% 时。它可能是控制与青少年肥胖相关的炎症过程的目标。