Limited information is available regarding the effect of Lactobacillus on the gut–bone axis. We examined whether 10‐week administration of milk products fermented by Lactobacillus fermentum MF27 and/or Lactobacillus casei 393 modified gut–bone dysbiosis induced by ovariectomy and lipopolysaccharide (OVX‐LPS) in rats. The fermented milk products selectively modulated gut microbiota composition and improved intestinal barrier function; they suppressed osteoclastogenesis, thereby increasing trabecular bone volume in OVX‐LPS rats. These findings suggest that the gut–bone axis can be modulated not only by viable Lactobacillus strains but also by milk products fermented by Lactobacillus, which may contain metabolites and/or bioactive peptides.

中文翻译：

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乳杆菌菌株发酵的奶制品在去卵巢小鼠模型中调节肠骨轴

关于乳杆菌对肠骨轴的作用的信息有限。我们检查了大鼠乳杆菌发酵液MF27和/或干酪乳杆菌393发酵乳制品经卵巢切除和脂多糖（OVX-LPS）诱导后是否能改善肠骨营养不良。发酵乳制品选择性调节肠道菌群组成并改善肠屏障功能；它们抑制破骨细胞生成，从而增加OVX-LPS大鼠的小梁骨体积。这些发现表明，肠-骨轴不仅可以由活的乳酸杆菌菌株调节，而且可以由乳酸杆菌发酵的乳制品调节，其中可能含有代谢产物和/或生物活性肽。