The current study aimed to investigate the anti‐osteoporotic effects of a Lactobacillus plantarum B719‐fermented milk product (FMP‐B719). Higher proliferation and mineralisation were observed in FMP‐B719‐treated MC3T3‐E1 mouse pre‐osteoblastic cells than those in L. casei ATCC 393‐FMP‐treated MC3T3‐E1 cells. Moreover, FMP‐B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy‐induced postmenopausal osteoporosis. Furthermore, FMP‐B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP‐B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.

中文翻译：

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植物乳杆菌B719发酵乳制品的骨骼保护作用

本研究旨在研究植物乳杆菌B719发酵乳制品（FMP-B719）的抗骨质疏松作用。在FMP-B719处理过的MC3T3-E1小鼠成骨细胞中观察到的增殖和矿化度高于干酪乳杆菌ATCC 393-FMP处理过的MC3T3-E1细胞。此外，在卵巢切除术引起的绝经后骨质疏松的大鼠模型中，FMP-B719使血清碱性磷酸酶（9.37±1.92 U / L）和磷（8.28±0.1 mg / dL）正常化。此外，FMP-B719使股骨近端的骨量正常化，并增加了去卵巢大鼠的股骨强度。因此，这项研究的结果表明FMP-B719可以作为治疗和预防绝经后骨质疏松症的潜在候选者。