In the present study, grafting of poly(methacrylic acid) (PMAA) onto various types of starches (maize; rice; wheat; potato) is realized in the aqueous media for the first time using methacrylic acid as monomer and ammonium cerium‐IV‐nitrate as initiator system. The effects of the gelatinization pretreatment and the use of a crosslinker in the grafting reactions are investigated. The formation of the starch‐graft‐poly(methacrylic acid) (S‐g‐PMAA) is confirmed by Fourier transform infrared spectroscopy analysis. The grafting amounts (GA%) of the S‐g‐PMAAs are determined. The swelling and the erosion characteristics of the S‐g‐PMAAs are examined in deionized water and pH = 5 lactate buffer solution as an in vitro vaginal medium. Mechanical and in vitro mucoadhesiveness of the S‐g‐PMAAs are also investigated using ewe vaginal mucosa. The results demonstrate that the gelatinization pretreatment and crosslinking significantly affect the GA% values, swelling, erosion, mechanical, and mucoadhesive characteristics of the S‐g‐PMAAs depending on the types of starches. S‐g‐PMAAs with different mechanical and reasonable mucoadhesiveness can be obtained by manipulating the grafting conditions and using various types of starches. It is concluded that S‐g‐PMAAs could be appropriate candidates for applications as vaginal drug delivery systems.

中文翻译：

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淀粉类型和接枝条件对淀粉-接枝-聚（甲基丙烯酸）水凝胶体外黏膜黏附性的影响

在本研究中，使用甲基丙烯酸作为单体和铈铈-IV-铵盐首次在水性介质中实现了将聚（甲基丙烯酸）（PMAA）接枝到各种类型的淀粉（玉米，大米，小麦，马铃薯）上硝酸盐作为引发剂体系。研究了糊化预处理的效果以及在接枝反应中使用交联剂的效果。所述淀粉的形成接枝-聚（甲基丙烯酸）（S-克-PMAA）通过傅立叶确认变换红外光谱分析。确定S- g- PMAA的接枝量（GA％）。所述S-的溶胀和侵蚀特性克‐PMAA在去离子水和pH = 5乳酸缓冲液中作为体外阴道介质进行检查。还使用母羊阴道粘膜研究了S- g- PMAA的机械和体外粘膜粘附性。结果表明，糊化预处理和交联显著影响GA％的值，肿胀，侵蚀，机械，和S-的粘膜粘附特征克取决于类型的淀粉-PMAAs。通过控制接枝条件并使用各种类型的淀粉，可以获得具有不同机械和合理的粘膜粘附性的S- g- PMAA。结论是，S- g- PMAAs可能适合作为阴道给药系统的应用。