von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration.,Evolution and Development

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von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration.
Evolution and Development ( IF 2.6 ) Pub Date : 2020-03-12 , DOI: 10.1111/ede.12332
Nicholas D Leigh _{1,

2} , Sofia Sessa ₁ , Aline C Dragalzew ₃ , Duygu Payzin-Dogru ₁ , Josane F Sousa ₃ , Anthony N Aggouras ₁ , Kimberly Johnson ₁ , Garrett S Dunlap ₁ , Brian J Haas ₂ , Michael Levin _{4,

5} , Igor Schneider ₃ , Jessica L Whited _{1,

2,

4}

Affiliation

Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema—a transient structure that houses a pool of progenitor cells that can regenerate the missing tissue. We have identified the expression of von Willebrand factor D and EGF domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species, including axolotl (Ambystoma mexicanum), lungfish (Lepidosiren paradoxa), and Polpyterus (Polypterus senegalus). Further, vwde expression is tightly linked to the ability to regenerate appendages in Xenopus laevis. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent growth factor in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily informed approach for identifying conserved genetic components of regeneration.

中文翻译：

von Willebrand 因子 D 和 EGF 结构域是能够进行多组织附属物再生的胚泡的进化上保守和必需的特征。

不同物种的再生能力差异很大。四肢、鳍、鹿角和尾巴等附属物再生的一个共同特征是胚泡的形成——一种短暂的结构，其中包含可以再生缺失组织的祖细胞池。我们已经确定von Willebrand 因子 D 和 EGF 结构域( vwde ) 的表达是能够在各种高度再生物种中再生四肢和鳍的胚泡的一个共同特征，包括蝾螈 ( Ambystoma mexicanum )、肺鱼 ( Lepidosiren paradoxa ) 和Polpyterus ( Polypterus senegalus )。此外，vwde表达与非洲爪蟾附肢再生能力密切相关。功能实验表明再生需要vwde，并表明 Vwde 是胚泡中的有效生长因子。这些数据确定了vwde在再生胚泡中的关键作用，并强调了进化信息方法在识别再生的保守遗传成分方面的力量。

更新日期：2020-03-12

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