miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.,FEBS Open Bio

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miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.
FEBS Open Bio ( IF 2.8 ) Pub Date : 2020-04-18 , DOI: 10.1002/2211-5463.12838
Wan Lin ₁ , Yu Miao ₁ , Xiangkun Meng ₁ , Ying Huang ₁ , Wanli Zhao ₂ , Jigang Ruan ₁

Affiliation

Elucidation of the mechanisms underlying multidrug resistance (MDR) is required to ensure the efficacy of chemotherapy against gastric cancer (GC). To investigate this issue, here we identified that microRNA‐765 (miRNA‐765) is up‐regulated both in MDR GC cell lines and in specimens from patients who are not responding to chemotherapy. In addition, down‐regulation of miRNA‐765 increased the sensitivity of GC cells to anticancer drugs, whereas its overexpression had the opposite effect. Moreover, miRNA‐765 suppressed drug‐induced apoptosis and positively regulated the expression of MDR‐related genes. Finally, we showed that the basic leucine zipper ATF‐like transcription factor 2, a tumor suppressor gene, is the functional target of miRNA‐765. In summary, these results suggest that miRNA‐765 may promote MDR via basic leucine zipper ATF‐like transcription factor 2 in GC cells.

中文翻译：

miRNA-765通过靶向胃癌细胞中的BATF2介导多药耐药性。

需要阐明多药耐药性（MDR）的潜在机制，以确保化学疗法抗胃癌（GC）的功效。为了研究这个问题，在这里我们发现MDR GC细胞系和对化疗无反应的患者标本中的microRNA-765（miRNA-765）均被上调。此外，miRNA-765的下调增加了GC细胞对抗癌药物的敏感性，而其过表达则相反。此外，miRNA-765抑制药物诱导的细胞凋亡，并积极调节MDR相关基因的表达。最后，我们证明了基本的亮氨酸拉链ATF样转录因子2（一种抑癌基因）是miRNA-765的功能靶标。综上所述，

更新日期：2020-04-18

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