Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.,FEBS Open Bio

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Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.
FEBS Open Bio ( IF 2.8 ) Pub Date : 2020-04-10 , DOI: 10.1002/2211-5463.12834
Xiao Meng Zhang ₁ , Yi Zhen Wang ₂ , Jin Dong Tong ₃ , Xu Chao Ning ₂ , Fang Qiang Zhou ₄ , Xiu Hong Yang ₁ , Hui Min Jin ₁

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Endoplasmic reticulum (ER) stress plays a critical role in the development of diabetic nephropathy (DN). We previously demonstrated that pyruvate (Pyr)‐enriched oral rehydration solution improved glucometabolic disorders and ameliorated DN outcome in db/db mice. Here, we investigated the effects of Pyr on high glucose‐induced ER stress and apoptosis in HK‐2 cells. Our results suggest that high glucose can induce reactive oxygen species production, apoptosis and ER stress in HK‐2 cells, and that Pyr treatment can ameliorate these effects and restore the expression of key proteins involved in ER stress. Thus, Pyr may have potential for the development of novel strategies for the prevention and treatment of clinical DN.

中文翻译：

丙酮酸可减轻高葡萄糖诱导的 HK-2 细胞内质网应激和细胞凋亡。

内质网（ER）应激在糖尿病肾病（DN）的发展中起着至关重要的作用。我们之前证明，富含丙酮酸 (Pyr) 的口服补液可以改善 db/db 小鼠的葡萄糖代谢紊乱并改善 DN 结局。在这里，我们研究了 Pyr 对高葡萄糖诱导的 HK-2 细胞内质网应激和细胞凋亡的影响。我们的结果表明，高葡萄糖可以诱导 HK-2 细胞中活性氧的产生、细胞凋亡和内质网应激，而 Pyr 治疗可以改善这些影响并恢复参与内质网应激的关键蛋白的表达。因此，Pyr 可能具有开发预防和治疗临床 DN 的新策略的潜力。

更新日期：2020-04-10

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