SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53.,FEBS Open Bio

当前位置： X-MOL 学术 › FEBS Open Bio › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53.
FEBS Open Bio ( IF 2.8 ) Pub Date : 2020-06-07 , DOI: 10.1002/2211-5463.12872
Fengjuan Chen _{1,

2} , Ka Zhang ₃ , Yilin Huang ₄ , Fang Luo ₁ , Kunpeng Hu ₅ , Qingxian Cai ₁

Affiliation

Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow module combined with PPI analysis. Verification of the role of these genes revealed that SPC25 knockdown results in a significant decrease in proliferation and metastasis of HCC cells and increased protein levels of components of the p53 pathway in vitro. In summary, we identified that SPC25 is a potential tumor‐promoting factor in HCC and may act via the p53 pathway.

中文翻译：

SPC25可能通过p53促进肝细胞癌的增殖和转移。

肝细胞癌（HCC）是一种常见的恶性肿瘤，预后差，死亡率高。为了确定与 HCC 相关的关键基因及其潜在机制，我们对 HCC 的潜在关键基因进行了加权相关网络分析 (WGCNA)。我们通过黄色模块结合PPI分析确定了与HCC密切相关的17个关键基因。对这些基因作用的验证表明，敲除 SPC25 可显着降低 HCC 细胞的增殖和转移，并增加体外p53 通路组分的蛋白质水平。总之，我们确定 SPC25 是 HCC 中潜在的肿瘤促进因子，可能通过 p53 途径起作用。

更新日期：2020-06-07

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11