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The genetic program to specify ectodermal cells in ascidian embryos.
Development, Growth & Differentiation ( IF 1.7 ) Pub Date : 2020-03-04 , DOI: 10.1111/dgd.12660
Boqi Liu 1 , Yutaka Satou 1
Affiliation  

The ascidian belongs to the sister group of vertebrates and shares many features with them. The gene regulatory network (GRN) controlling gene expression in ascidian embryonic development leading to the tadpole larva has revealed evolutionarily conserved gene circuits between ascidians and vertebrates. These conserved mechanisms are indeed useful to infer the original developmental programs of the ancestral chordates. Simultaneously, these studies have revealed which gene circuits are missing in the ascidian GRN; these gene circuits may have been acquired in the vertebrate lineage. In particular, the GRN responsible for gene expression in ectodermal cells of ascidian embryos has revealed the genetic programs that regulate the regionalization of the brain, formation of palps derived from placode‐like cells, and differentiation of sensory neurons derived from neural crest‐like cells. We here discuss how these studies have given insights into the evolution of these traits.

中文翻译:

该遗传程序用于确定海鞘胚胎中的外胚层细胞。

该海鞘属于脊椎动物的姊妹群,与它们具有许多共同特征。在导致to幼虫的海藻胚胎发育中控制基因表达的基因调控网络(GRN)已揭示了海藻和脊椎动物之间进化上保守的基因回路。这些保守的机制确实有助于推断祖先脊索动物的原始发育程序。同时,这些研究揭示了海鞘GRN中缺少哪些基因回路。这些基因回路可能是在脊椎动物谱系中获得的。特别是,负责在海藻胚胎的外胚层细胞中表达基因的GRN揭示了调控大脑区域化,从斑纹样细胞衍生出的触手形成的遗传程序,神经c样细胞衍生的感觉神经元的分化。我们在这里讨论这些研究如何对这些特征的演变提供见解。
更新日期:2020-03-04
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