Gene regulatory landscape of the sonic hedgehog locus in embryonic development.,Development, Growth & Differentiation

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Gene regulatory landscape of the sonic hedgehog locus in embryonic development.
Development, Growth & Differentiation ( IF 1.7 ) Pub Date : 2020-04-28 , DOI: 10.1111/dgd.12668
Takanori Amano ₁

Affiliation

The organs of vertebrate species display a wide variety of morphology. A remaining challenge in evolutionary developmental biology is to elucidate how vertebrate lineages acquire distinct morphological features. Developmental programs are driven by spatiotemporal regulation of gene expression controlled by hundreds of thousands of cis‐regulatory elements. Changes in the regulatory elements caused by the introduction of genetic variants can confer regulatory innovation that may underlie morphological novelties. Recent advances in sequencing technology have revealed a number of potential regulatory variants that can alter gene expression patterns. However, a limited number of studies demonstrate causal dependence between genetic and morphological changes. Regulation of Shh expression is a good model to understand how multiple regulatory elements organize tissue‐specific gene expression patterns. This model also provides insights into how evolution of molecular traits, such as gene regulatory networks, lead to phenotypic novelty.

中文翻译：

刺猬在胚胎发育中的基因调控景观。

脊椎动物物种的器官表现出各种各样的形态。进化发育生物学的另一个挑战是阐明脊椎动物谱系如何获得独特的形态特征。发育程序是由成百上千的顺式调控元件控制的基因表达的时空调控驱动的。由遗传变异的引入引起的调控元件的变化可以赋予可能在形态学新颖性基础上的调控创新。测序技术的最新进展已经揭示了许多可能改变基因表达模式的潜在调控变体。但是，有限的研究表明遗传和形态变化之间存在因果关系。嘘的规定表达是了解多个调控元件如何组织组织特异性基因表达模式的好模型。该模型还提供了有关分子特征（例如基因调控网络）进化如何导致表型新颖性的见识。

更新日期：2020-06-29

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