Non‐alcoholic fatty liver disease (NAFLD) is a metabolic disorder caused by excess consumption of hypercaloric foods. Guavira (Campomanesia sp.) pulp has broad technological applicability, yet the peel and seeds are considered industrial residue. The objective of this unprecedented study was to evaluate the effects of the flour from guavira's industrial residue (GF) consumption in rats fed with hypercaloric diet (HD). During 65 days, 50 rats were separated into a control group: 1%, 2%, 4% and 8% HD with GF complementation in the diet. The GF chemical composition, phenolic compounds, antioxidant capacity, serum biochemical parameters (glucose, cholesterol, HDL, non‐HDL, triglycerides, AST, ALT, and oral glucose tolerance test), fat liver content, and hepatic histomorphology had been characterized. GF is mainly composed of fibres, with phenolic content of 7,391.09 mg AGE/100 g GF and relevant antioxidant capacity (IC50 2.22 and ORAC 155.68 μmol/TE g⁻¹). Serum biochemical analysis did not differ statistically (except ALT reduction, p < .05). Fat liver content was smaller on HD2%GF (p < .0001). The control group and 1% GF showed greater diffuse microvesicular steatosis compared to the other groups when using hepatic morphological analysis (p < .05). GF consumption attenuated NAFLD caused by a hypercaloric diet, and this effect may be related to the fibre content and bioactive compounds in GF.

中文翻译：

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桔梗 面粉可减轻高热量饮食喂养的大鼠的非酒精性脂肪肝疾病。

非酒精性脂肪肝疾病（NAFLD）是一种因过度摄入高热量食物而引起的代谢性疾病。瓜维拉（Campomanesia纸浆具有广泛的技术适用性，但果皮和种子被视为工业残留物。这项史无前例的研究的目的是评估食用高热量饮食（HD）的番石榴工业残渣（GF）食用面粉对大鼠的影响。在65天中，将50只大鼠分为对照组：饮食中添加GF的HD分别为1％，2％，4％和8％。表征了GF的化学成分，酚类化合物，抗氧化能力，血清生化参数（葡萄糖，胆固醇，HDL，非HDL，甘油三酸酯，AST，ALT和口服葡萄糖耐量试验），脂肪肝含量和肝组织形态学。GF主要由纤维组成，酚含量为7,391.09 mg AGE / 100 g GF，具有一定的抗氧化能力（IC50 2.22和ORAC 155.68μmol/ TE g ^-1）。血清生化分析无统计学差异（除ALT降低外，p  <.05）。HD2％GF的脂肪肝含量较小（p  <.0001）。与其他组相比，对照组和1％GF表现出更大的弥漫性微囊脂肪变性（p  <.05）。高热量饮食会减少高热量饮食引起的NAFLD，这种作用可能与GF中的纤维含量和生物活性化合物有关。