The human body immune system, metabolism and homeostasis are affected by microbes. Dysbiosis occurs when the homeostatic equilibrium is disrupted due to an alteration in the normal microbiota of the intestine. Dysbiosis can cause cancer, and also affect a patient's ability to respond to treatment. Metataxonomics seeks to identify the bacteria present in a biological sample, based on the sequencing of the 16S rRNA genetic marker. Precision medicine attempts to find relationships between the microbiota and the risk of acquiring cancer, and design new therapies targeting bacteria. Flexible and portable bioinformatic pipelines are necessary to be able to bring metataxonomics to the clinical field, which allow groups of biological samples to be classified according to their diversity in the microbiota. With this aim we implemented Metatax, a new pipeline to analyze biological samples based on 16S rRNA gene sequencing. The results obtained with our pipeline should complement those obtained by sequencing a patient's DNA and RNA, in addition to clinical data, to improve knowledge of the possible reasons for a disease or a worse response to treatment.

中文翻译：

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Metatax：带有基于Compi的精密医学管道的Metataxonomics。

人体的免疫系统，新陈代谢和体内平衡受微生物的影响。当由于肠道正常微生物群的改变而导致体内平衡失调时，就会发生营养不良。营养不良会导致癌症，也影响患者对治疗的反应能力。基于16S rRNA遗传标记的测序，Metataxonomics寻求鉴定生物样品中存在的细菌。精密医学试图找到微生物群与患癌症风险之间的关系，并设计针对细菌的新疗法。灵活而便携的生物信息学管道对于将元分类学带入临床领域是必不可少的，这使得根据生物样品中生物样品的多样性可以对生物样品组进行分类。为此，我们实施了Metatax，基于16S rRNA基因测序的生物样品分析新管线。除临床数据外，通过我们的产品线获得的结果应补充通过对患者的DNA和RNA测序获得的结果，以增进对疾病或治疗反应较差的可能原因的了解。