Nanoparticles have different physical and chemical properties than those of micro-sized particles and are actively studied in the fields of electronics, biology, and material science. However, in case of most polymeric nanoparticles, maintaining and remaining in their colloid state for a long time is difficult due to self-aggregation. In this study, we examined the morphological, physical, and chemical properties of tunicate cellulose nanocrystals (tCNC) and also investigated the effect of tCNC on colloidal behaviors of poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles. Fourier-transform infrared spectroscopy (FTIR) showed that tCNC do not have a chemical effect on PLGA-based nanoparticles. Dynamic light scattering (DLS) showed that tCNC helped the PLGA nanoparticles maintain their small sizes for a longer period in solution. tCNC were also confirmed to be non-cytotoxic to human dermal fibroblasts at concentrations below 0.5%. Based on these results, tCNC were found to be a stabilizer for PLGA-based nanoparticles.

纳米粒子的物理和化学性质与微米尺寸的粒子不同，并且在电子，生物学和材料科学领域得到了积极的研究。然而，在大多数聚合物纳米颗粒的情况下，由于自聚集，很难长时间维持并保持其胶体状态。在这项研究中，我们检查了被膜纤维素纳米晶体（tCNC）的形态，物理和化学性质，还研究了tCNC对基于聚乳酸-乙醇酸（PLGA）的纳米粒子胶体行为的影响。傅立叶变换红外光谱（FTIR）表明tCNC对基于PLGA的纳米颗粒没有化学作用。动态光散射（DLS）表明，tCNC帮助PLGA纳米粒子在溶液中维持较小尺寸。浓度低于0.5％的tCNC也被证实对人真皮成纤维细胞无细胞毒性。基于这些结果，发现tCNC是基于PLGA的纳米颗粒的稳定剂。