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Epidermal antenna in palmar arch region for anaemia detection to avoid peripheral perfusion artifact in optical sensor during hemoglobin measurement
Microsystem Technologies ( IF 2.1 ) Pub Date : 2019-11-08 , DOI: 10.1007/s00542-019-04675-x
V. Kannagi , A. Jawahar

The anaemia disease diagnosed with various test such as complete blood count (CBC), ferritin measure, reticulocyte count, peripheral smear and blood gas analyser. The ferritin measure the storage and usage of iron in human body, reticulocyte count assess young red blood cell, and Peripheral smear analyse the cell colour, size, and shape of red blood cell through microscopic image. The blood gas analyser measures methemoglobin (MetHb) and carboxyhaemoglobin. Different test measure haemoglobin, since iron level show normal in blood for the patient with low total body iron. The iron deficiency never show symptom or sign in the human body. In this paper, we propose a new non-invasive method for anaemia measure through epidermal antenna over ulnar region of palm and acquire radiating signal from Haemoglobin protein. The acquired signal from epidermal antenna analysed with Transverse Dyadic Wavelet Transform for haemoglobin protein level in red blood cell. The epidermal antenna signal from ulnar region haemoglobin measurement avoids the peripheral perfusion artifact of optical or image sensor which arise during measurement. The experimental analysis show signal of epidermal antenna measure the haemoglobin more accurately, through regression modelling than existing optical and image based point of care device. Experimental result of haemoglobin measurement from ulnar region has validated with blood gas analyser.



中文翻译:

手掌弓区域的表皮触角用于贫血检测,以避免在血红蛋白测量期间光学传感器中的周边灌注伪影

贫血疾病可通过各种检查诊断,例如全血细胞计数(CBC),铁蛋白测定,网织红细胞计数,外周涂片和血气分析仪。铁蛋白测量人体中铁的存储和使用量,网织红细胞计数评估年轻的红细胞,外围涂片通过显微镜图像分析红细胞的颜色,大小和形状。血气分析仪可测量高铁血红蛋白(MetHb)和羧基血红蛋白。由于体内总铁含量低的患者血液中的铁含量正常,因此对血红蛋白的测试方法有所不同。缺铁永远不会在人体内出现症状或体征。在本文中,我们提出了一种新的非侵入性方法,通过表皮触角测量手掌尺骨区域的贫血,并从血红蛋白中获取辐射信号。从表皮天线获取的信号用横向二进小波变换分析红细胞中的血红蛋白水平。来自尺骨区域血红蛋白测量的表皮天线信号避免了在测量过程中出现的光学或图像传感器的周边灌注伪影。实验分析表明,与现有的基于光学和图像的护理设备相比,通过回归建模,表皮天线的信号可更准确地测量血红蛋白。用尺气分析仪验证了尺骨区域血红蛋白测量的实验结果。来自尺骨区域血红蛋白测量的表皮天线信号避免了在测量过程中出现的光学或图像传感器的周边灌注伪影。实验分析表明,与现有的基于光学和图像的护理设备相比,通过回归建模,表皮天线的信号可以更准确地测量血红蛋白。用尺气分析仪验证了尺骨区域血红蛋白测量的实验结果。来自尺骨区域血红蛋白测量的表皮天线信号避免了在测量过程中出现的光学或图像传感器的周边灌注伪影。实验分析表明,与现有的基于光学和图像的护理设备相比,通过回归建模,表皮天线的信号可以更准确地测量血红蛋白。用尺气分析仪验证了尺骨区域血红蛋白测量的实验结果。

更新日期:2019-11-08
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