Human pathogens need to overcome an elaborate network of host defense mechanisms in order to establish their infection, colonization, proliferation and eventual dissemination. The interaction of pathogens with different effector molecules of the immune system results in their neutralization and elimination from the host. The complement system is one such integral component of innate immunity that is critically involved in the early recognition and elimination of the pathogen. Hence, under this immune pressure, all virulent pathogens capable of inducing active infections have evolved immune evasive strategies that primarily target the complement system, which plays an essential and central role for host defense. Recent reports on several bacterial pathogens have elucidated the molecular mechanisms underlying complement evasion, inhibition of opsonic phagocytosis and cell lysis. This review aims to comprehensively summarize the recent findings on the various strategies adopted by pathogenic bacteria to escape complement-mediated clearance.

中文翻译：

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补充人类病原菌的逃避策略。

人类病原体需要克服宿主防御机制的复杂网络，以建立它们的感染、定植、增殖和最终传播。病原体与免疫系统的不同效应分子的相互作用导致它们从宿主中中和和消除。补体系统是先天免疫的一个组成部分，它与病原体的早期识别和消除密切相关。因此，在这种免疫压力下，所有能够诱导活动性感染的强毒病原体都进化出免疫逃避策略，主要针对补体系统，补体系统在宿主防御中起着重要和核心的作用。最近关于几种细菌病原体的报告阐明了补体逃避的分子机制，抑制调理性吞噬作用和细胞裂解。本综述旨在全面总结最近关于病原菌为逃避补体介导的清除而采用的各种策略的发现。