Alternaria species are mainly saprophytic fungi, but some pathotypes of Alternaria alternata infect economically important plants including cereal crops, vegetables and fruits. Specially, A. alternata generates toxins which contaminate food and feed. To date, management of A. alternata relies primarily on fungicides. However, the control efficacy in most cases is below expectation due to ubiquity of A. alternata and resistance to fungicides. To mitigate resistance and develop long-lasting fungicides, uncovering multiple rather than single target is a prerequisite. Membrane proteins are potential targets of fungicides owing to wide participation in myriad biochemical events especially material transport, signal transduction and pathogenicity. However, so far, little is known about the distribution and molecular structure of A. alternata membrane proteins (AAMPs). Herein we summarize AAMPs by data mining and subsequent structure prediction. We also outline the state-of-the-art research advances of AAMPs especially those closely related to pathogenicity. Overall, this review aims to portray a picture of AAMPs and provide valuable insights for future development of highly efficient fungicides towards A. alternata or beyond.

中文翻译：

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交替链格孢膜蛋白概述。

链格孢种主要是腐生菌，但一些致病型链格孢传染经济，包括谷物，蔬菜和水果的重要植物。特别地，A。轮叶藻会产生毒素，污染食物和饲料。迄今为止，A 的管理。交替链球菌主要依赖杀菌剂。然而，由于A 的普遍存在，大多数情况下的控制效果低于预期。交替和对杀菌剂的抗性。为了减轻耐药性并开发长效杀菌剂，发现多个目标而不是单个目标是先决条件。由于广泛参与无数生化事件，尤其是物质运输、信号转导和致病性，膜蛋白是杀菌剂的潜在目标。然而，到目前为止，知之甚少的分布和分子结构A.孢膜蛋白（AAMPs）。在此，我们通过数据挖掘和随后的结构预测来总结 AAMP。我们还概述了 AAMP 的最新研究进展，尤其是与致病性密切相关的研究进展。总体而言，这次审查的目的描绘AAMPs的图片和对高效杀菌剂的未来发展提供有价值的见解一个. 交替或超越。