As the SARS-CoV-2 virus race around the world across the different population, there needs to be a consolidated effort to understand the divergence of demographically distributed strains. The emerging trends in SARS-CoV-2 genome data show specific mutation and genetic diversity, which could provide the basis to develop a cocktail of vaccine and may also be used to develop the region-specific diagnostic tool, thus decreasing the chances of testing failures in fields. Since the transmission of SARS-CoV-2 is subject to the extent of human interaction, the insights from the correlation of genetic diversity with epidemiological parameter would give paramount information to tackle this transmission. Previously, studies have also correlated the epidemiological data with gut microbiome and its role in immunomodulation for maintaining health status, and such information could be generated from recovered individuals from different demographic regions. It will help in designing a probiotic-based diet for modulation of the gut microbiome, and that could be another plausible prophylactic treatment option. The genomics data suggest that a specific variant of SARS-CoV-2 gets enriched with the specific demographic region. Overall, demographic data suggests that host influences mutation and expression of the virus. Hence, the experiences from the clinical intervention for that region should be considered in control and treatment strategies.

中文翻译：

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了解 SARS-CoV-2：人类遗传多样性、传播和治疗。


随着 SARS-CoV-2 病毒在世界各地的不同人群中传播，需要共同努力来了解人口分布毒株的差异。 SARS-CoV-2基因组数据的新趋势显示出特定的突变和遗传多样性，这可以为开发混合疫苗提供基础，也可以用于开发特定区域的诊断工具，从而减少测试失败的机会在字段中。由于 SARS-CoV-2 的传播取决于人类互动的程度，因此从遗传多样性与流行病学参数的相关性中获得的见解将为解决这种传播提供重要信息。此前，研究还将流行病学数据与肠道微生物组及其在维持健康状态的免疫调节中的作用相关联，并且这些信息可以从不同人口区域的康复个体中产生。它将有助于设计一种基于益生菌的饮食来调节肠道微生物组，这可能是另一种看似合理的预防性治疗选择。基因组学数据表明，SARS-CoV-2 的特定变体随着特定的人口区域而丰富。总体而言，人口统计数据表明宿主影响病毒的突变和表达。因此，在控制和治疗策略中应考虑该地区临床干预的经验。