Here, a microgel of poly(_L‐Lysine) (p(LL)) from an amino acid, _L‐Lysine, was synthesized by microemulsion technique using AOT as surfactant in gasoline. The prepared p(LL) microgel was shown to be hydrolytically degradable at pH values of 5.4, 7.4, and 9 in phosphate buffer solution (PBS). The protonated p(LL) microgel was loaded with model drugs such as naproxen and riboflavin and found to release about 80% of loaded naproxen in 180 minutes and 70% of loaded riboflavin in about 120 minutes suggesting the potential of p(LL) microgels to act as fast drug delivery vehicles. Furthermore, p(LL) microgels were chemically modified with 1‐bromoethane (BE), 1‐bromooctane (BO), and 1‐bromoethylamine (BEA) to render antimicrobial capabilities. It was found that protonated p(LL) microgels had 29 ± 1 mm inhibition zone diameter for Pseudomonas aeruginosa ATCC 10145. Furthermore, minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) values for Staphylococcus aureus ATCC 6538 were also calculated as 1 and 2.5 mg/mL concentrations, respectively, for protonated p(LL) microgels.

中文翻译：

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氨基酸衍生的聚（L-赖氨酸）（p（LL））微凝胶作为通用生物材料：水解可降解，载药，化学修饰和抗菌材料

在此，聚微凝胶（_大号由氨基酸-赖氨酸）（P（LL）），_大号‐赖氨酸是通过微乳液技术使用AOT作为汽油中的表面活性剂合成的。制备的p（LL）微凝胶在磷酸盐缓冲溶液（PBS）中显示在pH值为5.4、7.4和9时可水解降解。质子化的p（LL）微凝胶上装有模型药物，如萘普生和核黄素，发现在180分钟内释放了约80％的萘普生，而在约120分钟内释放了70％的核黄素，表明p（LL）微凝胶有潜力充当快速的药物输送工具。此外，p（LL）微凝胶已通过1-溴乙烷（BE），1-溴辛烷（BO）和1-溴乙胺（BEA）进行了化学修饰，以提供抗菌能力。发现铜绿假单胞菌的质子化p（LL）微凝胶具有29±1 mm的抑制区直径ATCC 10145.此外，质子化的p（LL）微凝胶的金黄色葡萄球菌ATCC 6538的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）值也分别计算为1和2.5 mg / mL浓度。