Biodegradable polymers are widely used to manufacture biodegradable devices, such as those used in regenerative medicine. In many cases, nonuniform degradation can arise from nonuniform stress fields. The developed numerical methodology can simulate the mechanical behavior of three‐dimensional structures subjected to loads during degradation after a given degradation time, thus providing a valuable tool for pre validation of biodegradable devices. Degradation rate was assumed as linear function of the local von Mises stress. Material model parameters change as degradation proceeds and hydrolytic damage increases. Hence, shear modulus of the neo‐Hookean constitutive model was assumed as linear function of hydrolytic damage. The methodology was developed in a finite elements' framework using ABAQUS/Standard. The local hydrolytic damage and the consequent shear modulus evolutions were calculated by means of a user material subroutine. The stress field affects locally the kinetics of degradation and the evolution of hydrolytic damage. Thus, local hydrolytic damage and the material parameter are updated at each time step to recalculate stress and strain fields at the inputted degradation time. The aim of this work was to allow the simulation of biodegradable devices subjected to both mechanical and chemical environments.

中文翻译：

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考虑降解时间和非均质应力场的数值模拟生物可降解结构力学行为的方法

可生物降解的聚合物被广泛用于制造可生物降解的装置，例如用于再生医学的装置。在许多情况下，应力场不均匀会导致性能下降。所开发的数值方法可以模拟在给定的降解时间后降解过程中承受载荷的三维结构的机械行为，从而为生物可降解设备的预验证提供了有价值的工具。降解速率被认为是局部冯·米塞斯应力的线性函数。材料模型参数随着降解的进行和水解破坏的增加而变化。因此，新胡克本构模型的剪切模量被假定为水解损伤的线性函数。该方法是使用ABAQUS / Standard在有限元框架内开发的。通过用户材料子程序来计算局部水解损伤和随后的剪切模量演变。应力场局部影响降解动力学和水解破坏的演变。因此，在每个时间步长更新局部水解损伤和材料参数，以在输入的降解时间重新计算应力场和应变场。这项工作的目的是允许在机械和化学环境下模拟可生物降解的设备。在每个时间步长上更新局部水解损伤和材料参数，以在输入的降解时间重新计算应力场和应变场。这项工作的目的是允许在机械和化学环境下模拟可生物降解的设备。在每个时间步长上更新局部水解损伤和材料参数，以在输入的降解时间重新计算应力场和应变场。这项工作的目的是允许在机械和化学环境下模拟可生物降解的设备。