Soft tissue tumors can be categorized molecularly into two categories: tumors which are known to have recurrent molecular alterations and tumors which do not have consistent recurrent molecular alterations or translocations. These “nontranslocation” associated sarcomas are clinically more aggressive than their more stable counterparts. However, recent advances in RNA sequencing have discovered recurrent novel fusions within the latter group, namely TERT‐TRIO fusions. Furthermore, a recent report discovered this fusion in a spindle cell liposarcoma. Our case describes a novel fusion of CTNND2, a neighbor gene of TRIO, and TERT in a spindle cell liposarcoma, and provides further evidence that spindle cell liposarcoma should be a distinct entity from dedifferentiated liposarcoma.

中文翻译：

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梭状细胞脂肪肉瘤中的新型CTNND2-TERT融合。

软组织肿瘤可以在分子上分为两类：已知具有复发性分子改变的肿瘤和不具有一致的复发性分子改变或易位的肿瘤。这些“非易位”相关的肉瘤在临床上比其更稳定的肉瘤更具侵略性。但是，RNA测序的最新进展发现了后者中经常出现的新型融合蛋白，即TERT-TRIO融合蛋白。此外，最近的报道发现梭形细胞脂肪肉瘤中存在这种融合。我们的案例描述了梭状细胞脂肪肉瘤中TRIO的邻近基因CTNND2和TERT的新型融合，并提供了进一步的证据表明梭状细胞脂肪肉瘤应该与去分化的脂肪肉瘤是不同的实体。