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Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo.
Developmental Dynamics ( IF 2.0 ) Pub Date : 2020-04-30 , DOI: 10.1002/dvdy.186
Maureen C Lamb 1 , Kelsey K Anliker 1 , Tina L Tootle 1
Affiliation  

The actin bundling protein Fascin is essential for developmental cell migrations and promotes cancer metastasis. In addition to bundling actin, Fascin has several actin‐independent roles; how these other functions contribute to cell migration remains unclear. Border cell migration during Drosophila oogenesis provides an excellent model to study Fascin's various roles during invasive, collective cell migration.

中文翻译:

Fascin 调节突起和分层以在体内介导侵入性的集体细胞迁移。

肌动蛋白捆绑蛋白 Fascin 对于发育细胞迁移和促进癌症转移至关重要。除了捆绑肌动蛋白外,Fascin 还具有几个与肌动蛋白无关的作用。这些其他功能如何促进细胞迁移仍不清楚。果蝇卵子发生过程中的边界细胞迁移为研究 Fascin 在侵入性、集体细胞迁移过程中的各种作用提供了一个极好的模型。
更新日期:2020-04-30
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