Lignocellulosic biomass is the most abundant renewable source of bioenergy. However, its intertwined structures prevent the embedded cellulose and hemicellulose from undergoing further chemical transformations. Organosolv pretreatment has been known to be effective in reducing the recalcitrance of lignocellulosic biomass. It possesses advantages in the recovery of components and the recovered components such as cellulose can be converted into bioproducts through consolidated bioprocessing (CBP). The main objective of this paper is to review recent developments in organosolv pretreatment, including a comparison of different organic solvents and their optimum operation conditions in terms of pretreatment performance and efficiency. Conventional solvents were also compared with several emerging solvents to discover more potential utilization of organosolv pretreatment. This paper also reviewed fundamental knowledge regarding organosolv pretreatment such as its mechanism, and the chemical and physical properties of the solvents, which are still rarely discussed in the literature due to a lack of conclusive information. The challenges and way forward for organosolv pretreatment were also analyzed in depth to consider the synergistic advantages after the integration of organosolv pretreatment into CBP. It is believed that, through more fundamental exploration and optimization work, organosolv pretreatment can play a vital role in determining the sustainability of CBP, to pave the way for more efficient bioprocessing in the future. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd

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有机溶剂预处理的基本综述及其在新兴整合生物处理中的挑战

木质纤维素生物质是生物能源中最丰富的可再生资源。但是，其相互缠绕的结构阻止了嵌入的纤维素和半纤维素进行进一步的化学转化。已知有机溶剂预处理可有效减少木质纤维素生物质的顽固性。它在成分回收方面具有优势，回收的成分（如纤维素）可通过合并生物处理（CBP）转化为生物产品。本文的主要目的是回顾有机溶剂预处理的最新进展，包括比较各种有机溶剂及其在预处理性能和效率方面的最佳操作条件。还将常规溶剂与几种新兴溶剂进行了比较，以发现有机溶剂预处理的更多潜在用途。本文还回顾了有关有机溶剂预处理的基本知识，例如其机理以及溶剂的化学和物理性质，由于缺乏确凿的信息，因此在文献中仍然很少进行讨论。还对有机溶剂预处理的挑战和前进方向进行了深入分析，以考虑将有机溶剂预处理整合到CBP中后的协同优势。据信，通过更基础的探索和优化工作，有机溶剂预处理可以在确定CBP的可持续性方面发挥至关重要的作用，为将来更有效的生物处理铺平道路。