Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta‐analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published up to September 2018 and that compared the effect of Vitamin D‐fortified food versus regular diet in relation to glycemic control. Of the 4,379 studies originally found, 11 articles remained to be assessed for meta‐analysis. Vitamin D fortification was associated with a significant improvement in fasting serum glucose (mean difference [MD]: −2.772; 95% confidence interval [CI]: −5.435 to −0.109) and fasting serum insulin (MD: −2.937; 95% CI: −4.695 to −1.178) in patients with Type 2 diabetes mellitus. A diet with food enriched with Vitamin D was associated with a significant improvement in homeostatic model assessment of insulin resistance (MD: −1.608; 95% CI: −3.138 to −0.079) but was not associated with a significant reduction in hemoglobin A1C (MD: 0.034; 95% CI: −0.655 to 0.069). This meta‐analysis indicates that Vitamin D fortification improves indices of glycemic control. Hence, food fortified with Vitamin D may be of potential therapeutic value in diabetic patients, as an adjuvant therapy.

中文翻译：

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维生素 D 强化食品对血糖指数影响的系统评价和荟萃分析。

一些报告表明，维生素 D 可以改善糖尿病患者的血糖指数。这项系统和荟萃分析的目的是评估维生素 D 强化对血糖控制指标的影响。搜索了六个数据库（PubMed/Medline、ISI Web of Knowledge、Cochrane Library、Science Direct、Scopus 和 Google Scholar），搜索截至 2018 年 9 月发表的随机对照试验，这些试验比较了维生素 D 强化食品与与血糖控制相关的规律饮食。在最初发现的 4,379 项研究中，仍有 11 篇文章需要进行荟萃分析评估。维生素 D 强化与空腹血糖（平均差 [MD]：-2.772；95% 置信区间 [CI]：-5.435 至 -0.109）和空腹血清胰岛素（MD：-2.937；95% CI）的显着改善相关：-4.695 到 -1。178) 在 2 型糖尿病患者中。富含维生素 D 的饮食与胰岛素抵抗稳态模型评估的显着改善相关（MD：-1.608；95% CI：-3.138 至 -0.079），但与血红蛋白 A1C 的显着降低无关（MD ：0.034；95% CI：-0.655 至 0.069）。该荟萃分析表明，维生素 D 强化可改善血糖控制指数。因此，富含维生素 D 的食物作为辅助治疗可能对糖尿病患者具有潜在的治疗价值。034; 95% 置信区间：-0.655 至 0.069）。该荟萃分析表明，维生素 D 强化可改善血糖控制指数。因此，富含维生素 D 的食物作为辅助治疗可能对糖尿病患者具有潜在的治疗价值。034; 95% 置信区间：-0.655 至 0.069）。该荟萃分析表明，维生素 D 强化可改善血糖控制指数。因此，富含维生素 D 的食物作为辅助治疗可能对糖尿病患者具有潜在的治疗价值。