Pregnancy remains an immune challenge for the uterus that has to adapt to a semi‐allogeneic fetus using various regulatory mechanisms. Both HLA‐G and regulatory T cells (CD4⁺ CD25⁺ FOXP3⁺ T_regs) are upregulated in successful pregnancy, but not in abortion. It is unclear if HLA‐G plays a role in the upregulation of regulatory cells.

中文翻译：

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在维持健康怀孕期间，HLA-G在诱导调节性T细胞方面有作用吗？

怀孕仍然是子宫的免疫挑战，子宫必须通过各种调节机制适应半同种异体胎儿。HLA-G和调节性T细胞（CD4 ⁺  CD25 ⁺  FOXP3 ⁺  T _regs）在成功妊娠中均被上调，但在流产中则不上调。尚不清楚HLA-G是否在调节细胞的上调中起作用。