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Simultaneous Nanothermometry and Deep-Tissue Imaging.
Advanced Science ( IF 14.3 ) Pub Date : 2020-04-30 , DOI: 10.1002/advs.202000370 Pascal M Gschwend 1 , David Niedbalka 1, 2 , Lukas R H Gerken 3, 4 , Inge K Herrmann 3, 4 , Sotiris E Pratsinis 1
Advanced Science ( IF 14.3 ) Pub Date : 2020-04-30 , DOI: 10.1002/advs.202000370 Pascal M Gschwend 1 , David Niedbalka 1, 2 , Lukas R H Gerken 3, 4 , Inge K Herrmann 3, 4 , Sotiris E Pratsinis 1
Affiliation
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Bright, stable, and biocompatible fluorescent contrast agents operating in the second biological window (1000–1350 nm) are attractive for imaging of deep‐lying structures (e.g., tumors) within tissues. Ideally, these contrast agents also provide functional insights, such as information on local temperature. Here, water‐dispersible barium phosphate nanoparticles doped with Mn5+ are made by scalable, continuous, and sterile flame aerosol technology and explored as fluorescent contrast agents with temperature‐sensitive peak emission in the NIR‐II (1190 nm). Detailed assessment of their stability, toxicity with three representative cell lines (HeLa, THP‐1, NHDF), and deep‐tissue imaging down to about 3 cm are presented. In addition, their high quantum yield (up to 34%) combined with excellent temperature sensitivity paves the way for concurrent deep‐tissue imaging and nanothermometry, with biologically well‐tolerated nanoparticles.
中文翻译：
同步纳米测温和深层组织成像。
在第二生物窗口（1000-1350 nm）内工作的明亮、稳定且生物相容的荧光造影剂对于组织内深层结构（例如肿瘤）的成像很有吸引力。理想情况下，这些造影剂还可以提供功能见解，例如有关局部温度的信息。在这里，通过可扩展、连续和无菌火焰气溶胶技术制备了掺杂 Mn 5+的水分散性磷酸钡纳米粒子，并探索了作为在 NIR-II (1190 nm) 中具有温度敏感峰值发射的荧光造影剂。详细评估了它们的稳定性、三种代表性细胞系（HeLa、THP-1、NHDF）的毒性以及低至约 3 cm 的深部组织成像。此外，它们的高量子产率（高达 34%）与出色的温度敏感性相结合，为同时进行深层组织成像和纳米测温以及生物耐受性良好的纳米颗粒铺平了道路。
更新日期：2020-06-24
中文翻译：
同步纳米测温和深层组织成像。
在第二生物窗口（1000-1350 nm）内工作的明亮、稳定且生物相容的荧光造影剂对于组织内深层结构（例如肿瘤）的成像很有吸引力。理想情况下，这些造影剂还可以提供功能见解，例如有关局部温度的信息。在这里，通过可扩展、连续和无菌火焰气溶胶技术制备了掺杂 Mn 5+的水分散性磷酸钡纳米粒子，并探索了作为在 NIR-II (1190 nm) 中具有温度敏感峰值发射的荧光造影剂。详细评估了它们的稳定性、三种代表性细胞系（HeLa、THP-1、NHDF）的毒性以及低至约 3 cm 的深部组织成像。此外，它们的高量子产率（高达 34%）与出色的温度敏感性相结合，为同时进行深层组织成像和纳米测温以及生物耐受性良好的纳米颗粒铺平了道路。
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