当前位置: X-MOL 学术J. Recept. Signal Transduct. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The hidden role of the Sigma1 receptor in muscle cells
Journal of Receptors and Signal Transduction ( IF 2.8 ) Pub Date : 2020-02-14 , DOI: 10.1080/10799893.2020.1727924
Michał Skrzycki 1 , Beata Kaźmierczak 1
Affiliation  

Abstract This review describes the very specific role of Sigma1 receptor in different types of muscle cells. Sigma1 receptor is a transmembrane protein residing in such structures like MAM. It has chaperoning activity supporting function of many proteins, particularly ion channels, including Ca2+ channels. This latter function is of particular meaning for muscle cells, due to their calcium-based/regulated metabolism. Here we discuss new reports pointing to participation of Sigma1 receptor in muscle specific processes like contraction, EC-coupling, calcium currents and in diseases like left ventricular hypertrophy, transverse aortic stenosis and hypertension-induced heart dysfunction.

中文翻译:

Sigma1受体在肌肉细胞中的隐藏作用

摘要 本综述描述了 Sigma1 受体在不同类型肌肉细胞中的非常具体的作用。Sigma1 受体是一种跨膜蛋白,存在于 MAM 等结构中。它具有许多蛋白质的伴侣活性支持功能,尤其是离子通道,包括 Ca2+ 通道。由于其基于钙的/受调节的代谢,后一种功能对于肌肉细胞具有特殊意义。在这里,我们讨论了新的报告,这些报告指出 Sigma1 受体参与肌肉特定过程,如收缩、EC 偶联、钙电流,以及左心室肥厚、横向主动脉瓣狭窄和高血压引起的心脏功能障碍等疾病。
更新日期:2020-02-14
down
wechat
bug