Background

Silver nanoparticles (AgNPs) have anti-cancer effects with fewer side effects than standard chemotherapeutic agents, however, they exert oxidative stress-based adverse effects on normal cells and so their applications have raised concern about possible health and environmental risks.

Objective

We evaluated whether green tea extract (GTE), which contains potent antioxidants, could ameliorate AgNPs geno-, cyto-, and histotoxicities without decreasing their therapeutic potential against Ehrlich ascetic carcinoma (EAC).

Results

GTE enhanced the anti-cancer effect of AgNPs against EAC cells and ameliorated the genotoxic effect of AgNPs as indicated by lowering chromosomal aberrations and micronucleus frequencies. Additionally, GTE relieved most of degenerative histological changes induced by AgNPs. GTE restored the increased MDA and the decreased SOD, GPx and CAT serum levels induced by AgNPs to levels comparable to normal. The pre-treatment with GTE and AgNPs showed better improvement than the post-treatment strategy.

Conclusions

GTE can not only ameliorate AgNPs-induced adverse effects but also improve their anti-cancer effect against EAC. So, it could be useful in the treatment of liver dysfunction associated with AgNPs.

中文翻译：

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绿茶改善银纳米颗粒治疗小鼠艾氏腹水瘤的副作用

背景

银纳米颗粒（AgNP）具有抗癌作用，且副作用少于标准化学治疗剂，但是，它们对正常细胞产生基于氧化应激的不利影响，因此其应用引起了人们对健康和环境风险的担忧。

目的

我们评估了含有有效抗氧化剂的绿茶提取物（GTE）是否可以改善AgNPs的基因，细胞和组织毒性，而不会降低其对Ehrlich禁酒癌（EAC）的治疗潜力。

结果

GTE增强了AgNPs对EAC细胞的抗癌作用，并通过降低染色体畸变和微核频率来改善AgNPs的遗传毒性作用。此外，GTE缓解了由AgNPs诱导的大多数变性组织学变化。GTE将由AgNPs诱导的MDA恢复升高和SOD，GPx和CAT血清水平降低至正常水平。用GTE和AgNPs进行的预处理显示出比后处理策略更好的改善。

结论

GTE不仅可以改善AgNPs引起的不良反应，还可以改善其对EAC的抗癌作用。因此，它可用于治疗与AgNP相关的肝功能不全。