This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8 levels in GBS compared to the other groups (p < 0.05). IL-8 could be considered a potential biomarker to differentiate GBS from CIDP. This distinction could be relevant in terms of therapeutic decisions and functional prognosis.

该初步研究旨在比较格林-巴利综合征 (GBS) 和慢性炎症性脱髓鞘性多发性神经病 (CIDP) 患者脑脊液 (CSF) 中白细胞介素 8 (IL-8)（一种促炎趋化因子）的水平、非炎症性多发性神经病 (PNP) 和其他非炎症性神经系统疾病（功能性综合征或偏头痛）。结果显示，与其他组相比，GBS 中的 CSF IL-8 水平升高 (p < 0.05)。 IL-8 可以被认为是区分 GBS 和 CIDP 的潜在生物标志物。这种区别可能与治疗决策和功能预后相关。