PURPOSE We have recently demonstrated that absolute counts of circulating proinflammatory monocytes were lower in obese patients without metabolic syndrome (MS) (metabolically healthy obese, MHO) compared with those with MS (metabolically unhealthy obese, MUO), but higher compared with healthy lean controls (MHL). We hypothesized that circulating resistin, a cytokine secreted by white blood cells (WBC), is involved in obesity-related low-grade inflammation. The aim of this study was to (a) determine serum resistin levels among MUO and MHO subjects and (b) investigate the role of circulating WBC subsets as potential determinants of resistin. METHODS Study participants were 58 obese (33 MUO, 25 MHO) and 25 MHL individuals. Serum levels of resistin, high-sensitivity C-reactive protein (hsCRP), and absolute counts of circulating WBC subpopulations were determined. Comparisons were sex- and age-adjusted. RESULTS Serum resistin levels in MHL were lower compared with those of obese (p = 0.041), but similar to those of MHO (p = 0.856) individuals. Both resistin (p = 0.005) and absolute neutrophil count (NeuA) (p = 0.025) were higher in MUO compared with MHO. The difference in resistin levels between obese and MHL individuals disappeared after adjustment for NeuA. Resistin correlated positively with absolute total monocyte count (p = 0.037) in MHL and with body mass index (BMI) (p = 0.023), hsCRP (p = 0.022), and NeuA (p = 0.044) in obese subjects. Resistin association with ΒΜΙ disappeared after adjustment for hsCRP, while association with hsCRP disappeared after further adjustment for NeuA. CONCLUSION Circulating resistin was higher in MUO compared with MHO. The increased secretion of resistin by the greater number of neutrophils in the former may have contributed to this regulation.

中文翻译：

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代谢健康和不健康肥胖个体血清抵抗素水平的调节。

目的我们最近证明，与 MS 患者（代谢不健康肥胖，MUO）相比，没有代谢综合征 (MS) 的肥胖患者（代谢健康肥胖，MHO）中循环促炎单核细胞的绝对计数较低，但与健康瘦肉对照相比较高(MHL)。我们假设循环抵抗素，一种由白细胞 (WBC) 分泌的细胞因子，与肥胖相关的低度炎症有关。本研究的目的是 (a) 确定 MUO 和 MHO 受试者的血清抵抗素水平，以及 (b) 研究循环 WBC 亚群作为抵抗素的潜在决定因素的作用。方法 研究参与者为 58 名肥胖者（33 名 MUO，25 名 MHO）和 25 名 MHL 个体。血清抵抗素、高敏 C 反应蛋白 (hsCRP)、并确定了循环 WBC 亚群的绝对计数。比较是经过性别和年龄调整的。结果 MHL 的血清抵抗素水平低于肥胖者 (p = 0.041)，但与 MHO (p = 0.856) 个体相似。与 MHO 相比，MUO 中的抵抗素 (p = 0.005) 和绝对中性粒细胞计数 (NeuA) (p = 0.025) 均更高。调整 NeuA 后，肥胖和 MHL 个体之间抵抗素水平的差异消失。抵抗素与 MHL 中的绝对总单核细胞计数 (p = 0.037) 以及肥胖受试者中的体重指数 (BMI) (p = 0.023)、hsCRP (p = 0.022) 和 NeuA (p = 0.044) 呈正相关。在调整 hsCRP 后，抵抗素与 ΒΜl 的关联消失，而在进一步调整 NeuA 后，与 hsCRP 的关联消失。结论 与 MHO 相比，MUO 中的循环抵抗素更高。前者中更多的嗜中性粒细胞分泌的抵抗素增加可能促成了这种调节。