As zebrafish develop, black and gold stripes form across their skin due to the interactions of brightly colored pigment cells. These characteristic patterns emerge on the growing fish body, as well as on the anal and caudal fins. While wild-type stripes form parallel to a horizontal marker on the body, patterns on the tailfin gradually extend distally outward. Interestingly, several mutations lead to altered body patterns without affecting fin stripes. Through an exploratory modeling approach, our goal is to help better understand these differences between body and fin patterns. By adapting a prior agent-based model of cell interactions on the fish body, we present an in silico study of stripe development on tailfins. Our main result is a demonstration that two cell types can produce stripes on the caudal fin. We highlight several ways that bone rays, growth, and the body–fin interface may be involved in patterning, and we raise questions for future work related to pattern robustness.

中文翻译：

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对生长斑马鱼尾鳍的条纹形成进行建模

随着斑马鱼的发育，由于颜色鲜艳的色素细胞的相互作用，它们的皮肤上会形成黑色和金色的条纹。这些特征图案出现在生长的鱼体上，以及臀鳍和尾鳍上。虽然野生型条纹与身体上的水平标记平行，但尾鳍上的图案逐渐向远侧向外延伸。有趣的是，一些突变会导致身体模式改变，而不会影响鳍条。通过探索性建模方法，我们的目标是帮助更好地了解身体和鳍图案之间的这些差异。通过采用先前基于代理的鱼体细胞相互作用模型，我们对尾鳍上的条纹发育进行了计算机模拟研究。我们的主要结果是证明两种细胞类型可以在尾鳍上产生条纹。