Multiple sclerosis (MS) as chronic autoimmune inflammatory neurological disease of the central nervous system (CNS) occurs due to several environmental and genetic factors, whose pathogenesis is associated with genes with regulatory role in the immune system. Long non-coding RNAs (LncRNAs) are able to reportedly regulate responses of immune systems and expression of genes, and show the tissue specificity and complexity of biofunctions. Various studies have suggested that the aberrant LncRNA expression is an underlying factor involved in the incidence of MS and that the analysis of the expression profile of these molecules can be a specific biomarker of MS for preventing the course of the disease or responding to treatment. The purpose of this research was to review the recent studies for exploring the functions of LncRNAs in the processes leading to MS disease.

中文翻译：

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长非编码RNA（LncRNA）在多发性硬化中的作用：简要回顾。

多发性硬化症（MS）作为中枢神经系统（CNS）的慢性自身免疫炎性神经系统疾病，是由于多种环境和遗传因素而发生的，其发病机理与在免疫系统中具有调节作用的基因有关。据报道，长的非编码RNA（LncRNA）能够调节免疫系统的反应和基因表达，并显示出组织特异性和生物功能的复杂性。各种研究表明，异常的LncRNA表达是MS发病的一个潜在因素，这些分子表达谱的分析可能是MS预防疾病进程或对治疗产生反应的特定生物标记。