Previous studies have shown that environmental exposure to heavy metals has been related to epigenetic changes, such as DNA methylation in receptors involved in pathogenesis of asthma. One of these receptors is beta-2 adrenergic receptor (ADRB2). We conducted this study to examine the association between blood aluminum concentration, blood ADRB2 5' untranslated region (5'-UTR) methylation level, and childhood asthma control level. Our results showed a significant positive association between high blood aluminum concentration (odds ratio, 16, 95% confidence interval (CI) [3.57 to 71.76], p < 0.001) and high blood ADRB2 5'-UTR methylation level (odds ratio, 4.75, 95% CI [1.39 to 16.2], p = 0.013), and risk of uncontrolled asthma. Multivariable logistic regression revealed that higher blood aluminum concentration was independently associated with increased risk of uncontrolled bronchial asthma (odds ratio, 9.10, 95% CI [2.38 to 34.85], p = 0.0013], after controlling for age, sex, and blood ADRB2 5'-UTR methylation level. In addition, blood ADRB2 5'-UTR methylation level significantly correlated with whole blood aluminum concentration in asthmatic children (r = 0.480, p < 0.001). We concluded that increasing blood aluminum concentration is an important independent correlate of risk for uncontrolled bronchial asthma as well as increased blood aluminum concentration caused ADRB2 5'-UTR hyper-methylation with increasing risk of uncontrolled bronchial asthma.

中文翻译：

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血铝和β-2受体基因甲基化与儿童哮喘控制的关联。

先前的研究表明，环境中重金属的暴露与表观遗传学变化有关，例如与哮喘发病机制有关的受体中的DNA甲基化。这些受体之一是β-2肾上腺素能受体（ADRB2）。我们进行了这项研究，以检查血液铝浓度，血液ADRB2 5'非翻译区（5'-UTR）甲基化水平与儿童哮喘控制水平之间的关联。我们的结果表明，高血铝浓度（比值16，95％置信区间（CI）[3.57至71.76]，p <0.001）与高血ADRB2 5'-UTR甲基化水平（比值4.75）之间存在显着正相关。 ，95％CI [1.39至16.2]，p = 0.013），以及哮喘不受控制的风险。p = 0.0013]，控制了年龄，性别和血液ADRB2 5'-UTR甲基化水平之后。此外，哮喘儿童的血液ADRB2 5'-UTR甲基化水平与全血铝浓度显着相关（r = 0.480，p <0.001）。我们得出的结论是，血铝浓度升高是支气管哮喘不受控制风险的重要独立相关因素，而血铝浓度升高导致ADRB2 5'-UTR超甲基化与支气管哮喘不受控制的风险增加有关。p = 0.0013]，控制了年龄，性别和血液ADRB2 5'-UTR甲基化水平之后。此外，哮喘儿童的血液ADRB2 5'-UTR甲基化水平与全血铝浓度显着相关（r = 0.480，p <0.001）。我们得出的结论是，血铝浓度升高是支气管哮喘不受控制风险的重要独立相关因素，而血铝浓度升高导致ADRB2 5'-UTR超甲基化与支气管哮喘不受控制的风险增加有关。